20.500.12556/DiRROS-28623 The association between adult IgA vasculitis and cancer a prospective observational study Objectives: Cancer has been reported as a potential trigger for IgA vasculitis (IgAV) in adults; however, data on this topic are scarce. The aim of our study was to examine the frequency and location of cancer in adults with IgAV. Methods: We included 295 IgAV patients diagnosed between January 2010 and June 2021 and followed at our secondary/tertiary rheumatology centre. Cancer episodes were recorded and classified into three groups according to their temporal relation to IgAV: (1) cancer diagnosed prior to IgAV; (2) cancer diagnosed concurrently with IgAV; and (3) cancer diagnosed during IgAV follow-up. The term IgAV associated with cancer (IgAV-CA) was used for IgAV cases presenting while cancer was active or diagnosed within a three-year period before or after the IgAV diagnosis. Results: Forty-seven IgAV patients (15.9%) developed a total of 56 different cancers. Of these, 43 cancers (76.8%) preceded the IgAV diagnosis, 3 cancers (5.3%) were diagnosed concurrently with IgAV, and 10 cancers (17.9%) were diagnosed during the IgAV follow-up. Twenty-two IgAV patients (7.5%) who developed a total of 24 cancers (42.9%) could be classified as IgAV-CA cases. The three most frequently diagnosed cancers in the IgAV-CA group were prostatic, renal and bladder cancer, together accounting for 50% of cancers. Age and smoking were associated with concurrent cancers, and arthritis represented a risk factor for cancer development during IgAV follow-up. Conclusion: IgAV cases associated with cancer represent 7% of adult IgAV cases. In elderly patients, careful examination of the urogenital tract is warranted when cancer is suspected. adult IgA vasculitis cancer risk factor temporal relation urogenital cancers vaskulitis IgA pri odraslih rak (medicina) dejavniki tveganja časovna povezava rak urogenitalnega sistema true false true Angleški jezik Slovenski jezik Neznano 2026-03-26 09:47:19 2026-03-26 09:47:20 2026-03-28 03:43:55 0000-00-00 00:00:00 2025 0 0 str. 1-8 iss. , [article no.] 1551772 Vol. 12 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-002: 616-006 2296-858X 10.3389/fmed.2025.1551772 271245059 RAZ_Hocevar_Alojzija_2025.pdf RAZ_Hocevar_Alojzija_2025.pdf 1 6C1F7FB964DA287A2AA299B7B9CF2ABA 0d0b648dbef82b77f9bda5a0800cb959df192f75b3ac1b98e4c41e99be75185c 8c6de454-28f0-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42521 https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1551772/full 1 68c6bcd6-28f0-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42520 Univerzitetni klinični center Ljubljana 0 0 0