| Title: | Impact of chronic obstructive pulmonary disease on short-term outcome in patients with ST-elevation myocardial infarction during COVID-19 pandemic : insights from the international multicenter ISACS-STEMI registry |
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| Authors: | ID De Luca, Giuseppe (Author)
ID Nardin, Matteo (Author)
ID Algowhary, Magdy (Author)
ID Uguz, Berat (Author)
ID Oliveira, Dinaldo C. (Author)
ID Ganyukov, Vladimir (Author)
ID Zimbakov, Zan (Author)
ID Čerček, Miha (Author)
ID Okkels Jensen, Lisette (Author)
ID Loh, Poay Huan (Author), et al. |
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| Files: |  PDF - Presentation file, download (1,02 MB)
MD5: C55D06B1222DCD7F34611D0E37DDBB8C
 URL - Source URL, visit https://link.springer.com/article/10.1186/s12931-022-02128-0
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background: Chronic obstructive pulmonary disease (COPD) is projected to become the third cause of mortality worldwide. COPD shares several pathophysiological mechanisms with cardiovascular disease, especially atherosclero‑ sis. However, no definite answers are available on the prognostic role of COPD in the setting of ST elevation myocar‑ dial infarction (STEMI), especially during COVID-19 pandemic, among patients undergoing primary angioplasty, that is therefore the aim of the current study. Methods: In the ISACS-STEMI COVID-19 registry we included retrospectively patients with STEMI treated with pri‑ mary percutaneous coronary intervention (PCI) between March and June of 2019 and 2020 from 109 high-volume primary PCI centers in 4 continents. Results: A total of 15,686 patients were included in this analysis. Of them, 810 (5.2%) subjects had a COPD diagnosis. They were more often elderly and with a more pronounced cardiovascular risk profile. No preminent procedural dis‑ similarities were noticed except for a lower proportion of dual antiplatelet therapy at discharge among COPD patients (98.9% vs. 98.1%, P=0.038). With regards to short-term fatal outcomes, both in-hospital and 30-days mortality occurred more frequently among COPD patients, similarly in pre-COVID-19 and COVID-19 era. However, after adjust‑ ment for main baseline differences, COPD did not result as independent predictor for in-hospital death (adjusted OR [95% CI]=0.913[0.658–1.266], P=0.585) nor for 30-days mortality (adjusted OR [95% CI]=0.850 [0.620–1.164], P=0.310). No significant differences were detected in terms of SARS-CoV-2 positivity between the two groups. Conclusion: This is one of the largest studies investigating characteristics and outcome of COPD patients with STEMI undergoing primary angioplasty, especially during COVID pandemic. COPD was associated with significantly higher rates of in-hospital and 30-days mortality. However, this association disappeared after adjustment for baseline charac‑ teristics. Furthermore, COPD did not significantly affect SARS-CoV-2 positivity. |
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| Keywords: | COPD, STEMI, COVID-19 |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2022 |
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| Number of pages: | 9 str. |
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| Numbering: | Vol. 23, iss. 1, [article no.] 207 |
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| PID: | 20.500.12556/DiRROS-28587  |
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| UDC: | 616.12 |
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| ISSN on article: | 1465-993X |
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| DOI: | 10.1186/s12931-022-02128-0 |
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| COBISS.SI-ID: | 272827139 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 24. 3. 2026;
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| Publication date in DiRROS: | 24.03.2026 |
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| Views: | 33 |
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| Downloads: | 10 |
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