20.500.12556/DiRROS-28587 Impact of chronic obstructive pulmonary disease on short-term outcome in patients with ST-elevation myocardial infarction during COVID-19 pandemic insights from the international multicenter ISACS-STEMI registry Background: Chronic obstructive pulmonary disease (COPD) is projected to become the third cause of mortality worldwide. COPD shares several pathophysiological mechanisms with cardiovascular disease, especially atherosclero‑ sis. However, no definite answers are available on the prognostic role of COPD in the setting of ST elevation myocar‑ dial infarction (STEMI), especially during COVID-19 pandemic, among patients undergoing primary angioplasty, that is therefore the aim of the current study. Methods: In the ISACS-STEMI COVID-19 registry we included retrospectively patients with STEMI treated with pri‑ mary percutaneous coronary intervention (PCI) between March and June of 2019 and 2020 from 109 high-volume primary PCI centers in 4 continents. Results: A total of 15,686 patients were included in this analysis. Of them, 810 (5.2%) subjects had a COPD diagnosis. They were more often elderly and with a more pronounced cardiovascular risk profile. No preminent procedural dis‑ similarities were noticed except for a lower proportion of dual antiplatelet therapy at discharge among COPD patients (98.9% vs. 98.1%, P=0.038). With regards to short-term fatal outcomes, both in-hospital and 30-days mortality occurred more frequently among COPD patients, similarly in pre-COVID-19 and COVID-19 era. However, after adjust‑ ment for main baseline differences, COPD did not result as independent predictor for in-hospital death (adjusted OR [95% CI]=0.913[0.658–1.266], P=0.585) nor for 30-days mortality (adjusted OR [95% CI]=0.850 [0.620–1.164], P=0.310). No significant differences were detected in terms of SARS-CoV-2 positivity between the two groups. Conclusion: This is one of the largest studies investigating characteristics and outcome of COPD patients with STEMI undergoing primary angioplasty, especially during COVID pandemic. COPD was associated with significantly higher rates of in-hospital and 30-days mortality. However, this association disappeared after adjustment for baseline charac‑ teristics. Furthermore, COPD did not significantly affect SARS-CoV-2 positivity. COPD STEMI COVID-19 KOPB STEMI COVID-19 true false true Angleški jezik Slovenski jezik Neznano 2026-03-24 14:53:20 2026-03-24 14:53:21 2026-03-27 03:53:59 0000-00-00 00:00:00 2022 0 0 Nasl. z nasl. zaslona; Opis vira z dne 24. 3. 2026; 9 str. iss. 1, [article no.] 207 Vol. 23 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.12 1465-993X 10.1186/s12931-022-02128-0 272827139 RAZ_De_Luca_Giuseppe_2022.pdf RAZ_De_Luca_Giuseppe_2022.pdf 1 C55D06B1222DCD7F34611D0E37DDBB8C 4eb287cd675016edef8691c3d6c120628b9deb14c199570944fb8cdb7fffbf66 176a8fbe-2789-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42449 https://link.springer.com/article/10.1186/s12931-022-02128-0 1 d3669d33-2788-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42446 Univerzitetni klinični center Ljubljana 0 0 0