| Title: | Transcriptome profiles of skeletal muscle in krškopolje and modern hybrid pigs : genotype comparison and effects of dietary protein reduction |
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| Authors: | ID Vrecl, Milka (Author)
ID Fazarinc, Gregor (Author)
ID Štrbenc, Malan (Author)
ID Poklukar Žnidaršič, Klavdija (Author)
ID Čandek-Potokar, Marjeta (Author)
ID Škrlep, Martin (Author) |
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| Files: |  URL - Source URL, visit https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE320088
Description: Podatki nedostopni, 20. 3. 2026, dostopni po 20. 2. 2030
 PDF - Presentation file. (361,31 KB, This file will be accessible after 23.03.2030)
MD5: 12F5E839ECC95EB69287C0B52E4FF85E
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| Language: | English |
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| Typology: | 2.20 - Complete scientific database of research data |
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| Organization: |  KIS - Agricultural Institute of Slovenia
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| Abstract: | RNA sequencing was performed to compare two pig breeds (the Slovenian Krškopolje breed and a modern commercial breed) and to evaluate the effect of breed specific dietary protein reduction on the transcriptomic profiles of two skeletal muscles: longissimus thoracis et lumborum (LD) and semispinalis capitis (SSC). Differentially expressed genes (DEGs) were identified using the criteria |log2FC| > 1 and q value < 0.005. The effect of dietary protein reduction was minimal in both breeds and muscles, with only small numbers of DEGs detected. In Krškopolje pigs receiving medium protein (MP) or low protein (LP) diets, no DEGs were identified. In contrast, in the modern breed, 10 DEGs were detected when comparing the high protein (HP) with the MP diet group. A similar pattern was observed in SSC, where 19 DEGs were detected in Krškopolje pigs (MP vs. LP) and 16 DEGs in the modern breed (HP vs. LP). In comparison, when the LD and SSC transcriptome profiles of the modern breed were compared with those of the Krškopolje breed, the number of DEGs was substantially higher:149 in LD and 201 in SSC. The DEGs in LD of modern breed reflect a shift toward faster growing, more glycolytic muscle with distinct immune and neuromuscular regulation. Likewise, the SSC of modern breed shows stronger activation of growth related and metabolic signaling pathways. |
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| Keywords: | RNA sequences, pigs, adipose tissue, high throughput sequencing, RNA, transcriptome profiles, gene expression, locel breeds, hybrid breeds, data, data set |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 23.03.2026 |
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| Place of publishing: | Bethesda |
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| Place of performance: | Bethesda |
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| Publisher: | Gene Expression Omnibus (GEO) |
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| Year of publishing: | 2026 |
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| Year of performance: | 2026 |
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| Number of pages: | 1 spletni vir |
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| PID: | 20.500.12556/DiRROS-28562  |
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| UDC: | 636 |
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| COBISS.SI-ID: | 272740099 |
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| Note: | Nasl. z. nasl. zaslona;
Opis vira z dne 24. 3. 2026;
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| Publication date in DiRROS: | 24.03.2026 |
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| Views: | 207 |
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| Downloads: | 37 |
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