| Title: | Amyloid-▫$\beta$▫ 1-42 fibrils regulate SH-SY5Y cell adhesion in a delayed manner |
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| Authors: | ID Pečar Fonović, Urša (Author)
ID Kralj, Slavko, Institut "Jožef Stefan" (Author)
ID Kos, Janko, Institut "Jožef Stefan" (Author) |
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| Files: |  URL - Source URL, visit https://journals.sagepub.com/doi/10.1177/13872877261429855
 PDF - Presentation file, download (858,46 KB)
MD5: E5A7993F94C68AAF40E828DF1D0D8D61
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  IJS - Jožef Stefan Institute
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| Abstract: | Amyloid-β peptide (Aβ), a hallmark peptide in the pathology of Alzheimer's disease, together with the amyloid-β protein precursor, is increasingly associated with the disruption of cell adhesion. In addition to its well-characterized role in plaque formation and synaptic dysfunction, Aβ interacts with various adhesion molecules and extracellular matrix components, thereby impairing neuronal connectivity and integrity. We have shown that pretreatment of SH-SY5Y cells with Aβ42 fibrils affects cell adhesion; however, we did not observe this effect with Aβ42 monomers. Understanding the molecular mechanisms by which Aβ fibrils disrupt cell adhesion pathways may reveal new therapeutic approaches to prevent disease progression. |
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| Keywords: | amiloid beta, amyloid-beta fibrils |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 10.11.2025 |
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| Article acceptance date: | 30.01.2026 |
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| Publication date: | 18.03.2026 |
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| Publisher: | IOS Press |
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| Year of publishing: | 2026 |
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| Number of pages: | str. 1-5 |
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| Numbering: | Vol. 110, iss. |
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| Source: | Nizozemska |
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| PID: | 20.500.12556/DiRROS-28455  |
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| UDC: | 577 |
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| ISSN on article: | 1875-8908 |
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| DOI: | 10.1177/138728772614298 |
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| COBISS.SI-ID: | 272228867 |
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| Copyright: | © The Author(s) 2026 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 19. 3. 2026;
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| Publication date in DiRROS: | 20.03.2026 |
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| Views: | 207 |
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| Downloads: | 136 |
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