20.500.12556/DiRROS-28455 Amyloid-▫$\beta$▫ 1-42 fibrils regulate SH-SY5Y cell adhesion in a delayed manner Amyloid-β peptide (Aβ), a hallmark peptide in the pathology of Alzheimer's disease, together with the amyloid-β protein precursor, is increasingly associated with the disruption of cell adhesion. In addition to its well-characterized role in plaque formation and synaptic dysfunction, Aβ interacts with various adhesion molecules and extracellular matrix components, thereby impairing neuronal connectivity and integrity. We have shown that pretreatment of SH-SY5Y cells with Aβ42 fibrils affects cell adhesion; however, we did not observe this effect with Aβ42 monomers. Understanding the molecular mechanisms by which Aβ fibrils disrupt cell adhesion pathways may reveal new therapeutic approaches to prevent disease progression. amiloid beta amyloid-beta fibrils amiloid beta fibrile amiloidnega peptida beta true false true IOS Press Nizozemska Angleški jezik Slovenski jezik © The Author(s) 2026 Neznano 2026-03-20 08:51:31 2026-03-20 08:51:32 2026-03-26 03:47:19 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 19. 3. 2026; str. 1-5 iss. Vol. 110 [in press] 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2025-11-10 2026-01-30 2026-03-18 577 1875-8908 10.1177/138728772614298 272228867 https://journals.sagepub.com/doi/10.1177/13872877261429855 1 9e38bd1d-2431-11f1-b469-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42155 RAZ_Pecar_Fonovic_Ursa_2026.pdf RAZ_Pecar_Fonovic_Ursa_2026.pdf 1 E5A7993F94C68AAF40E828DF1D0D8D61 0d3701a3e573e1d80b0c6319d42b182a2a8b89fcd69a7202eca6db6738d6f2f0 fcc15a2e-2431-11f1-b469-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42156 Institut Jožef Stefan 0 0 0