| Title: | Prognostic impact of interleukin-27 in peripheral artery disease |
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| Authors: | ID Kokalj, Nataša (Author)
ID Jug, Borut (Author) |
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| Files: |  PDF - Presentation file, download (474,04 KB)
MD5: 3112065C18EAF4C33CDAB7D744A52952
 URL - Source URL, visit https://www.mdpi.com/2075-1729/15/11/1768
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Atherosclerosis is a progressive arterial disease characterized by chronic inflammation, with interleukin-27 (IL-27) implicated as both a pro- and anti-inflammatory cytokine. This prospective cohort study evaluated association of circulating IL-27 levels in peripheral artery disease patients undergoing elective endovascular revascularization, with major adverse cardiovascular events (MACE) and major adverse limb events (MALE) over a median follow-up of 311 days. Elevated IL-27 levels were significantly associated with increased risk of MACE and MALE in unadjusted analyses. After adjusting for established cardiovascular and PAD risk factors, IL-27 remained an independent predictor of MACE (HR 2.95; p = 0.039), but not MALE. These findings indicate that elevated IL-27 levels are associated with unfavourable long-term prognosis. |
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| Keywords: | peripheral artery disease, interleukin-27, endovascular revascularization, major adverse cardiovascular events, major adverse limb events |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 1-10 |
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| Numbering: | Vol. 15, issue 11, [article no.] 1768 |
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| PID: | 20.500.12556/DiRROS-28035  |
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| UDC: | 616.1 |
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| ISSN on article: | 2075-1729 |
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| DOI: | 10.3390/life15111768 |
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| COBISS.SI-ID: | 270807811 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 6. 3. 2026;
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| Publication date in DiRROS: | 06.03.2026 |
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| Views: | 29 |
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| Downloads: | 23 |
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| Metadata: |    |
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