20.500.12556/DiRROS-28035 Prognostic impact of interleukin-27 in peripheral artery disease Atherosclerosis is a progressive arterial disease characterized by chronic inflammation, with interleukin-27 (IL-27) implicated as both a pro- and anti-inflammatory cytokine. This prospective cohort study evaluated association of circulating IL-27 levels in peripheral artery disease patients undergoing elective endovascular revascularization, with major adverse cardiovascular events (MACE) and major adverse limb events (MALE) over a median follow-up of 311 days. Elevated IL-27 levels were significantly associated with increased risk of MACE and MALE in unadjusted analyses. After adjusting for established cardiovascular and PAD risk factors, IL-27 remained an independent predictor of MACE (HR 2.95; p = 0.039), but not MALE. These findings indicate that elevated IL-27 levels are associated with unfavourable long-term prognosis. peripheral artery disease interleukin-27 endovascular revascularization major adverse cardiovascular events major adverse limb events true false true Angleški jezik Ni določen Neznano 2026-03-06 15:20:16 2026-03-06 15:20:16 2026-03-07 03:51:46 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 6. 3. 2026; str. 1-10 issue 11, [article no.] 1768 Vol. 15 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616.1 2075-1729 10.3390/life15111768 270807811 Prognostic_Impact_of_Interleukin-27_in_Peripheral_Artery_Disease.pdf Prognostic_Impact_of_Interleukin-27_in_Peripheral_Artery_Disease.pdf 1 3112065C18EAF4C33CDAB7D744A52952 247f6d551e24914e40673adbde08df5a8a7df118b0f8e7b61abcc4acec867ece c5b7c686-1967-11f1-81cd-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41381 https://www.mdpi.com/2075-1729/15/11/1768 0 d5027bdb-1967-11f1-81cd-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41382 Univerzitetni klinični center Ljubljana 0 0 0