| Title: | Identifying risk factors for blood culture negative infective endocarditis : an international ID-IRI study |
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| Authors: | ID Mine, Filiz (Author)
ID Erdem, Hakan (Author)
ID Ankarali, Handan (Author)
ID Puca, Edmond (Author)
ID Ruch, Yvon (Author)
ID Santos, Lurdes (Author)
ID Fasciana, Teresa (Author)
ID Giammanco, Anna (Author)
ID Ghanem-Zoubi, Nesrin (Author)
ID Lejko-Zupanc, Tatjana (Author), et al. |
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| Files: |  PDF - Presentation file, download (1,03 MB)
MD5: BFEA7641DD1A2FCA20317308061B2B3A
 URL - Source URL, visit https://doi.org/10.1016/j.nmni.2024.101453
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background: Blood culture-negative endocarditis (BCNE) is a diagnostic challenge, therefore our objective was to pinpoint high-risk cohorts for BCNE. Methods: The study included adult patients with definite endocarditis. Data were collected via the Infectious Diseases International Research Initiative (ID-IRI). The study analysing one of the largest case series ever reported was conducted across 41 centers in 13 countries. We analysed the database to determine the predictors of BCNE using univariate and logistic regression analyses. Results: Blood cultures were negative in 101 (11.65 %) of 867 patients. We disclosed that as patients age, the likelihood of a negative blood culture significantly decreases (OR 0.975, 95 % CI 0.963–0.987, p < 0.001). Additionally, factors such as rheumatic heart disease (OR 2.036, 95 % CI 0.970–4.276, p = 0.049), aortic stenosis (OR 3.066, 95 % CI 1.564–6.010, p = 0.001), mitral regurgitation (OR 1.693, 95 % CI 1.012–2.833, p = 0.045), and prosthetic valves (OR 2.539, 95 % CI 1.599–4.031, p < 0.001) are associated with higher likelihoods of negative blood cultures. Our model can predict whether a patient falls into the culture-negative or culturepositive groups with a threshold of 0.104 (AUC±SE = 0.707 ± 0.027). The final model demonstrates a sensitivity of 70.3 % and a specificity of 57.0 %. Conclusion: Caution should be exercised when diagnosing endocarditis in patients with concurrent cardiac disorders, particularly in younger cases. |
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| Keywords: | infective endocarditis, blood culture, rheumatic heart disease, prosthetic valves, cardiac disorders, risk factors |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-6 |
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| Numbering: | Vol. 60-61, [article no.] 101453 |
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| PID: | 20.500.12556/DiRROS-27934  |
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| UDC: | 616.9 |
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| ISSN on article: | 2052-2975 |
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| DOI: | 10.1016/j.nmni.2024.101453 |
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| COBISS.SI-ID: | 236820739 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 22. 5. 2025;
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| Publication date in DiRROS: | 27.02.2026 |
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| Views: | 130 |
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| Downloads: | 51 |
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