20.500.12556/DiRROS-27934 Identifying risk factors for blood culture negative infective endocarditis an international ID-IRI study Background: Blood culture-negative endocarditis (BCNE) is a diagnostic challenge, therefore our objective was to pinpoint high-risk cohorts for BCNE. Methods: The study included adult patients with definite endocarditis. Data were collected via the Infectious Diseases International Research Initiative (ID-IRI). The study analysing one of the largest case series ever reported was conducted across 41 centers in 13 countries. We analysed the database to determine the predictors of BCNE using univariate and logistic regression analyses. Results: Blood cultures were negative in 101 (11.65 %) of 867 patients. We disclosed that as patients age, the likelihood of a negative blood culture significantly decreases (OR 0.975, 95 % CI 0.963–0.987, p < 0.001). Additionally, factors such as rheumatic heart disease (OR 2.036, 95 % CI 0.970–4.276, p = 0.049), aortic stenosis (OR 3.066, 95 % CI 1.564–6.010, p = 0.001), mitral regurgitation (OR 1.693, 95 % CI 1.012–2.833, p = 0.045), and prosthetic valves (OR 2.539, 95 % CI 1.599–4.031, p < 0.001) are associated with higher likelihoods of negative blood cultures. Our model can predict whether a patient falls into the culture-negative or culturepositive groups with a threshold of 0.104 (AUC±SE = 0.707 ± 0.027). The final model demonstrates a sensitivity of 70.3 % and a specificity of 57.0 %. Conclusion: Caution should be exercised when diagnosing endocarditis in patients with concurrent cardiac disorders, particularly in younger cases. infective endocarditis blood culture rheumatic heart disease prosthetic valves cardiac disorders risk factors infekcijski endokarditis hemokultura revmatična bolezen srca protetične zaklopke bolezni srca dejavniki tveganja true false true Angleški jezik Slovenski jezik Neznano 2026-02-27 13:39:28 2026-02-27 13:39:29 2026-02-28 04:21:01 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 22. 5. 2025; str. 1-6 [article no.] 101453 Vol. 60-61 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 2052-2975 10.1016/j.nmni.2024.101453 236820739 RAZ_Mine_Filiz_2024.pdf RAZ_Mine_Filiz_2024.pdf 1 BFEA7641DD1A2FCA20317308061B2B3A 1b14b82bac3b255d83246a1597853feed40609d7dc925d8ac4801e9a1a908ab2 93614135-13d9-11f1-8c73-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41138 https://doi.org/10.1016/j.nmni.2024.101453 0 a7443dab-13d9-11f1-8c73-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41139 Univerzitetni klinični center Ljubljana 0 0 0