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Title: Vloga cisteinske peptidaze katepsina X pri polarizaciji celic mikroglije Authors: ID Kovačič, Klara (Author) ID Pišlar, Anja (Author) Files: PDF - Presentation file, download (1,55 MB) MD5: BDAF1F9896B7063AE9C2054EFB541EC6   Language: Slovenian Typology: 1.01 - Original Scientific Article Organization: SFD - Slovenian Pharmaceutical Society Abstract: Celice mikroglije so glialne celice centralnega živčnega sistema, podobne makrofagom, ki vzdržujejo homeostazo možganov in so ene izmed najpomembnejših prirojenih celic imunskega sistema centralnega živčevja. Pod vplivom patoloških in imunoloških dražljajev pride do polarizacije mikroglije v pro-vnetni fenotip M1, ki spodbuja procese nevro - vnetja, ali proti-vnetni fenotip M2, ki izkazuje zaščitno delovanje v možganih. Cisteinski katepsini, ki jih sprošča polarizirana mikroglija fenotipa M1, so vse bolj prepoznani kot pomembni vnetni dejavniki, ki sprožijo signalne poti, kar dodatno vzpodbudi vnetne procese in vodi v nevrodegeneracijo. Med njimi je cisteinska peptidaza katepsin X, ki je že bila prepoznana kot patogeni dejavnik nevrodegeneracije, povzročene z vnetjem, vendar je njena vloga pri polarizaciji mikroglije v posamezen fenotip nepoznana. Rezultati raziskav nakazujejo, da ima katepsin X pomembno vlogo pri polarizaciji mikroglije v pro-vnetni fenotip M1 oziroma proti-vnetni fenotip M2 in predstavlja potencialno terapevtsko tarčo za preprečevanje in zdravljenje nevrodegenerativnih bolezni, povezanih s prekomernim vnetjem. Keywords: katepsin X, mikroglija, polarizacija, vnetje, zaviralec katepsina X Publication status: Published Publication version: Version of Record Publication date: 01.07.2025 Year of publishing: 2025 Number of pages: str. 151-159 Numbering: Letn. 76, št. 3 PID: 20.500.12556/DiRROS-27589  UDC: 616-097 ISSN on article: 0014-8229 COBISS.SI-ID: 245763587  Publication date in DiRROS: 13.02.2026 Views: 45 Downloads: 9 Metadata:    Cite this work Plain text BibTeX EndNote XML EndNote/Refer RIS ABNT ACM Ref AMA APA Chicago 17th Author-Date Harvard IEEE ISO 690 MLA Vancouver : Copy citation

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Record is a part of a journal

Title:	Farmacevtski vestnik : strokovno glasilo slovenske farmacije
Shortened title:	Farm. vestn.
Publisher:	Slovensko farmacevtsko društvo
ISSN:	0014-8229
COBISS.SI-ID:	3105794

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License:	CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
Link:	http://creativecommons.org/licenses/by-nc/4.0/
Description:	A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.

Secondary language

Language:	English
Title:	Role of cysteine peptidase cathepsin X in microglia polarization
Abstract:	Microglia are glial cells of the central nervous system, similar to macrophages, which maintain homeostasis of the brain and are among the most important cells of the innate immune system of the central nervous system. Under the influence of pathological and immunological stimuli, a polarization of microglia occurs, either into the proinflammatory phenotype M1, which promotes the processes of neuroinflammation, or into the antiinflammatory phenotype M2, which exhibits a protective function in the brain. Cysteine cathepsins, which are released by polarized microglia of the M1 phenotype are increasingly recognized as important inflammatory factors that trigger signaling pathways that further promote inflammatory processes and lead to neurodegeneration. These include the cysteine peptidase cathepsin X, which has already been recognized as a pathogenic factor in inflammation-induced neurodegeneration, but whose role in the polarization of microglia into a specific phenotype is still unknown. The obtained results suggest that cathepsin X plays an important role in the polarization of microglia into the proinflammatory M1 and the anti-inflammatory M2 phenotype and thus represents a potential therapeutic target for the prevention and treatment of neurodegenerative diseases associated with excessive inflammation.
Keywords:	cathepsin X, cathepsin X inhibitor, inflammation, microglia, polarization

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