20.500.12556/DiRROS-27589 Vloga cisteinske peptidaze katepsina X pri polarizaciji celic mikroglije Role of cysteine peptidase cathepsin X in microglia polarization Celice mikroglije so glialne celice centralnega živčnega sistema, podobne makrofagom, ki vzdržujejo homeostazo možganov in so ene izmed najpomembnejših prirojenih celic imunskega sistema centralnega živčevja. Pod vplivom patoloških in imunoloških dražljajev pride do polarizacije mikroglije v pro-vnetni fenotip M1, ki spodbuja procese nevro - vnetja, ali proti-vnetni fenotip M2, ki izkazuje zaščitno delovanje v možganih. Cisteinski katepsini, ki jih sprošča polarizirana mikroglija fenotipa M1, so vse bolj prepoznani kot pomembni vnetni dejavniki, ki sprožijo signalne poti, kar dodatno vzpodbudi vnetne procese in vodi v nevrodegeneracijo. Med njimi je cisteinska peptidaza katepsin X, ki je že bila prepoznana kot patogeni dejavnik nevrodegeneracije, povzročene z vnetjem, vendar je njena vloga pri polarizaciji mikroglije v posamezen fenotip nepoznana. Rezultati raziskav nakazujejo, da ima katepsin X pomembno vlogo pri polarizaciji mikroglije v pro-vnetni fenotip M1 oziroma proti-vnetni fenotip M2 in predstavlja potencialno terapevtsko tarčo za preprečevanje in zdravljenje nevrodegenerativnih bolezni, povezanih s prekomernim vnetjem. Microglia are glial cells of the central nervous system, similar to macrophages, which maintain homeostasis of the brain and are among the most important cells of the innate immune system of the central nervous system. Under the influence of pathological and immunological stimuli, a polarization of microglia occurs, either into the proinflammatory phenotype M1, which promotes the processes of neuroinflammation, or into the antiinflammatory phenotype M2, which exhibits a protective function in the brain. Cysteine cathepsins, which are released by polarized microglia of the M1 phenotype are increasingly recognized as important inflammatory factors that trigger signaling pathways that further promote inflammatory processes and lead to neurodegeneration. These include the cysteine peptidase cathepsin X, which has already been recognized as a pathogenic factor in inflammation-induced neurodegeneration, but whose role in the polarization of microglia into a specific phenotype is still unknown. The obtained results suggest that cathepsin X plays an important role in the polarization of microglia into the proinflammatory M1 and the anti-inflammatory M2 phenotype and thus represents a potential therapeutic target for the prevention and treatment of neurodegenerative diseases associated with excessive inflammation. katepsin X mikroglija polarizacija vnetje zaviralec katepsina X cathepsin X cathepsin X inhibitor inflammation microglia polarization true false true Slovenski jezik Angleški jezik Neznano 2026-02-13 16:03:29 2026-02-13 16:03:30 2026-02-14 04:04:40 0000-00-00 00:00:00 2025 0 0 str. 151-159 št. 3 Letn. 76 julij 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2025-07-01 616-097 0014-8229 245763587 katepsin.pdf katepsin.pdf 1 BDAF1F9896B7063AE9C2054EFB541EC6 8bf9e886dbab07b0dbc99561ddcc741105c5d337582f9672cf713c3b4fef8889 2b0feb2b-08ed-11f1-bcbc-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40433 Slovensko farmacevtsko društvo Farmacevtski vestnik 0 0 0