| Title: | Implications of sex differences in orthostatic tolerance during exposure to acute artificial gravity |
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| Authors: | ID Fisher, Jason T., Institut "Jožef Stefan" (Author)
ID Mekjavić, Igor B., Institut "Jožef Stefan" (Author)
ID Ciuha, Urša, Institut "Jožef Stefan" (Author) |
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| Files: |  URL - Source URL, visit https://www.nature.com/articles/s41526-025-00516-6
 PDF - Presentation file, download (771,61 KB)
MD5: 056336FC1D6EA4EB2A94CDAF62922276
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  IJS - Jožef Stefan Institute
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| Abstract: | Development of countermeasures to minimise spaceflight deconditioning is of paramount importance, such as the short-arm human centrifuge (SAHC); however, sex differences in cardiovascular responses should be considered. 20 participants (female = 10, male = 10) conducted an identical centrifugation protocol of 10-min phases of standing (NG), 1Gz centrifugation (1GRF), and 2Gz centrifugation (2GRF). Separated by 10-min each in hot (29.1 ± 0.8 °C) conditions, and either normoxia (PO2 = 133 mmHg) or hypoxia (PO2 = 92 mmHg). Haemodynamics, microvascular blood flow (arm and leg) and temperatures (skin and gastrointestinal) were continuously recorded. At 2GRF, females lasted 2.7 ± 1.6 min less than males. Arm blood flow significantly decreased, and leg blood flow increased, in 2GRF (p > 0.001); with higher female leg blood flow in 2GRF (p = 0.002). 2GRF altered all haemodynamic variables and females exhibited significantly higher heart rate, and lower stroke volume index (p < 0.001). Female participants exhibited greater cardiovascular strain, and encountered pre-syncopal symptoms earlier, during 2GRF. Future research should consider individualised and tolerable gravitational loads. |
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| Keywords: | artificial gravity, cardiovascular response, microvascular blood flow, haemodynamics |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 21.08.2024 |
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| Article acceptance date: | 28.07.2025 |
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| Publication date: | 12.08.2025 |
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| Publisher: | Nature Publishing Group |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 1-9 |
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| Numbering: | Vol. 11, article no. 55 |
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| Source: | ZDA |
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| PID: | 20.500.12556/DiRROS-27012  |
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| UDC: | 612 |
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| ISSN on article: | 2373-8065 |
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| DOI: | 10.1038/s41526-025-00516-6 |
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| COBISS.SI-ID: | 249987331 |
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| Copyright: | © The Author(s) 2025 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 23. 9. 2025;
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| Publication date in DiRROS: | 28.01.2026 |
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| Views: | 63 |
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| Downloads: | 29 |
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| Metadata: |    |
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