20.500.12556/DiRROS-27012 Implications of sex differences in orthostatic tolerance during exposure to acute artificial gravity Development of countermeasures to minimise spaceflight deconditioning is of paramount importance, such as the short-arm human centrifuge (SAHC); however, sex differences in cardiovascular responses should be considered. 20 participants (female = 10, male = 10) conducted an identical centrifugation protocol of 10-min phases of standing (NG), 1Gz centrifugation (1GRF), and 2Gz centrifugation (2GRF). Separated by 10-min each in hot (29.1 ± 0.8 °C) conditions, and either normoxia (PO2 = 133 mmHg) or hypoxia (PO2 = 92 mmHg). Haemodynamics, microvascular blood flow (arm and leg) and temperatures (skin and gastrointestinal) were continuously recorded. At 2GRF, females lasted 2.7 ± 1.6 min less than males. Arm blood flow significantly decreased, and leg blood flow increased, in 2GRF (p > 0.001); with higher female leg blood flow in 2GRF (p = 0.002). 2GRF altered all haemodynamic variables and females exhibited significantly higher heart rate, and lower stroke volume index (p < 0.001). Female participants exhibited greater cardiovascular strain, and encountered pre-syncopal symptoms earlier, during 2GRF. Future research should consider individualised and tolerable gravitational loads. artificial gravity cardiovascular response microvascular blood flow haemodynamics umetna gravitacija kardiovaskularni odziv pretok krvi hemodinamika true false true Nature Publishing Group ZDA Angleški jezik Slovenski jezik © The Author(s) 2025 Neznano 2026-01-28 14:34:22 2026-01-28 14:34:23 2026-02-01 04:00:59 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 23. 9. 2025; str. 1-9 Vol. 11, article no. 55 12 Aug. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-08-21 2025-07-28 2025-08-12 612 2373-8065 10.1038/s41526-025-00516-6 249987331 https://www.nature.com/articles/s41526-025-00516-6 1 1295ef8b-fc4e-11f0-a15d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=39649 RAZ_Fisher_Jason_T._2025.pdf RAZ_Fisher_Jason_T._2025.pdf 1 056336FC1D6EA4EB2A94CDAF62922276 779b319ad6e16b087038ce32655aee53f7d1a2164b26d4545eef2ae33d298339 af1c5fb4-fc4e-11f0-a15d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=39650 Institut Jožef Stefan 0 0 0