| Title: | Stomach cancer elective surgery morbidity and mortality at 90-Day (Hold Study) : a prospective, international collaborative cohort study |
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| Authors: | ID Neves-Marques, Claudia (Author)
ID Abulazayem, Mohamed (Author)
ID Wong, Geoffrey Yuet Mun (Author)
ID Maldonado, Ricardo David (Author)
ID Viswanath, Yirupaiahgari (Author)
ID Grosek, Jan (Author)
ID Košir, Jurij Aleš (Author)
ID Tomažič, Aleš (Research coworker), et al. |
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| Files: |  PDF - Presentation file, download (1,34 MB)
MD5: CFE802C15C5324B5044F6CF2D1C2EBA0
 URL - Source URL, visit https://link.springer.com/article/10.1007/s00423-025-03890-7
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background: Data on multinational 90-day mortality and morbidity rates after surgery for gastric cancer is limited in the literature. This study aimed to understand the 90-day mortality and morbidity outcomes among patients undergoing elective gastric cancer surgery, as in the GASTRODATA Registry, and to identify associated risk factors. Methods: We conducted an international prospective study on patients aged ≥ 18 years undergoing elective surgery for gastric cancer with curative intent from January 4 to September 30, 2022. Known metastatic disease, concurrent secondary cancers, gastrointestinal stromal tumour (GIST) and Siewert type I/II oesophagogastric junction malignancies were excluded. Univariate and multivariate logistic regression were used to identify variables associated with the 90-day outcome. Results: 380 collaborators from 47 countries submitted data on 1538 patients. Median age was 65 years (IQR: 19–94), and 58.5% were males. 90-day morbidity and mortality rates were 38.2% (n = 587) and 2.9% (n = 45), respectively. Pre-operative higher Charlson Comorbidity Index, higher ASA score, pre-operative weight loss > 10%, positive specimen margin, and post-operative pathological IV staging (p value < 0.05) were significantly associated with clinically relevant complications and mortality. Conclusion: Elective gastric cancer surgery has a 90-day morbidity of 38.2% and a 90-day mortality of 2.9% globally. This study provided the most comprehensive international 90-day prospective data to date regarding gastric cancer surgery. Several factors associated with higher morbidity were identified, highlighting the importance of a unified language on surgical morbidity, prehabilitation, and ongoing audits to enhance patient outcomes. |
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| Keywords: | gastric cancer, elective surgery, morbidity, mortality, 90-day postoperative outcomes, multinational audit, surgical complications, anastomotic leaks, patient safety |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2026 |
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| Number of pages: | str. 1-16 |
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| Numbering: | Vol. 411, issue 1, [article no.] 12 |
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| PID: | 20.500.12556/DiRROS-24735  |
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| UDC: | 616.3 |
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| ISSN on article: | 1435-2451 |
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| DOI: | 10.1007/s00423-025-03890-7 |
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| COBISS.SI-ID: | 257716995 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 19. 11. 2025;
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| Publication date in DiRROS: | 16.12.2025 |
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| Views: | 6 |
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| Downloads: | 5 |
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