20.500.12556/DiRROS-24735 Stomach cancer elective surgery morbidity and mortality at 90-Day (Hold Study) a prospective, international collaborative cohort study Background: Data on multinational 90-day mortality and morbidity rates after surgery for gastric cancer is limited in the literature. This study aimed to understand the 90-day mortality and morbidity outcomes among patients undergoing elective gastric cancer surgery, as in the GASTRODATA Registry, and to identify associated risk factors. Methods: We conducted an international prospective study on patients aged ≥ 18 years undergoing elective surgery for gastric cancer with curative intent from January 4 to September 30, 2022. Known metastatic disease, concurrent secondary cancers, gastrointestinal stromal tumour (GIST) and Siewert type I/II oesophagogastric junction malignancies were excluded. Univariate and multivariate logistic regression were used to identify variables associated with the 90-day outcome. Results: 380 collaborators from 47 countries submitted data on 1538 patients. Median age was 65 years (IQR: 19–94), and 58.5% were males. 90-day morbidity and mortality rates were 38.2% (n = 587) and 2.9% (n = 45), respectively. Pre-operative higher Charlson Comorbidity Index, higher ASA score, pre-operative weight loss > 10%, positive specimen margin, and post-operative pathological IV staging (p value < 0.05) were significantly associated with clinically relevant complications and mortality. Conclusion: Elective gastric cancer surgery has a 90-day morbidity of 38.2% and a 90-day mortality of 2.9% globally. This study provided the most comprehensive international 90-day prospective data to date regarding gastric cancer surgery. Several factors associated with higher morbidity were identified, highlighting the importance of a unified language on surgical morbidity, prehabilitation, and ongoing audits to enhance patient outcomes. gastric cancer elective surgery morbidity mortality 90-day postoperative outcomes multinational audit surgical complications anastomotic leaks patient safety postoperativni izidi puščanje anastomoze elektivne operacije rak želodca obolevnost smrtnost multinacionalna raziskava postoperativni zapleti true false true Angleški jezik Slovenski jezik Neznano 2025-12-16 12:21:53 2025-12-16 12:21:53 2025-12-17 03:58:00 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 19. 11. 2025; str. 1-16 issue 1, [article no.] 12 Vol. 411 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.3 1435-2451 10.1007/s00423-025-03890-7 257716995 RAZ_Neves-Marques_Claudia_2026.pdf RAZ_Neves-Marques_Claudia_2026.pdf 1 CFE802C15C5324B5044F6CF2D1C2EBA0 a58fd2851030bc6f5cf7a0ff13eb5ce1144b1d04d87127188339d0360c131d03 9e631180-da71-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36959 https://link.springer.com/article/10.1007/s00423-025-03890-7 0 b2ac633e-da71-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36960 Univerzitetni klinični center Ljubljana 0 0 0