| Title: | Impact of macrolide antibiotics on gut microbiota diversity with age-specific implications and scientific insights |
|---|
| Authors: | ID Shayista, H. (Author)
ID Chouhan, Raghuraj S., Institut "Jožef Stefan" (Author)
ID Baker, Syed (Author), et al. |
|---|
| Files: |  URL - Source URL, visit https://www.sciencedirect.com/science/article/pii/S2590097825000035?via%3Dihub
 PDF - Presentation file, download (2,63 MB)
MD5: 699DBEF77359FC31D40162268C8B30D3
|
|---|
| Language: | English |
|---|
| Typology: | 1.01 - Original Scientific Article |
|---|
| Organization: |  IJS - Jožef Stefan Institute
|
|---|
| Abstract: | This review investigates the effects of macrolides on the gut microbiota across different age groups. Macrolides, widely used to treat various infections, have been shown to disrupt the gut microbiome, leading to reduced bacterial diversity and increased risks of antibiotic resistance. The review examines the general mechanisms of action by macrolides, highlighting their role in inhibiting bacterial protein synthesis and promoting antibiotic resistance through horizontal gene transfer and selective pressure. Additionally, the reviews also focus on transition of gut microbiota across different age groups. It also addresses the dysbiotic shift induced by macrolides and its recovery following antibiotic discontinuation. Factors contributing to macrolides resistance, including genetic mutations and environmental factors, are discussed. The focus has been on alternative therapeutic approaches highlighted to mitigate resistance. Overall, the review provides a comprehensive overview of the implications associated with macrolides on gut health and offers insights into managing and minimizing resistance development. |
|---|
| Keywords: | gut microbiota, antibiotic resistance, different age groups, analysis |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Submitted for review: | 05.07.2024 |
|---|
| Article acceptance date: | 06.02.2025 |
|---|
| Publication date: | 13.02.2025 |
|---|
| Publisher: | Elsevier |
|---|
| Year of publishing: | 2025 |
|---|
| Number of pages: | 1-15 str. |
|---|
| Numbering: | Vol. 24, 100122 |
|---|
| Source: | Nizozemska |
|---|
| PID: | 20.500.12556/DiRROS-24713  |
|---|
| UDC: | 579 |
|---|
| ISSN on article: | 2590-0978 |
|---|
| DOI: | 10.1016/j.medmic.2025.100122 |
|---|
| COBISS.SI-ID: | 238702083 |
|---|
| Copyright: | © 2025 The Authors. |
|---|
| Note: | Nasl. z nasl. zaslona;
Soavtor Raghuraj Singh Chouhan;
Opis vira z dne 9. 6. 2025;
|
|---|
| Publication date in DiRROS: | 15.12.2025 |
|---|
| Views: | 8 |
|---|
| Downloads: | 8 |
|---|
| Metadata: |    |
|---|
|
:
|
Copy citation |
|---|
| | | | Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
