20.500.12556/DiRROS-24713 Impact of macrolide antibiotics on gut microbiota diversity with age-specific implications and scientific insights This review investigates the effects of macrolides on the gut microbiota across different age groups. Macrolides, widely used to treat various infections, have been shown to disrupt the gut microbiome, leading to reduced bacterial diversity and increased risks of antibiotic resistance. The review examines the general mechanisms of action by macrolides, highlighting their role in inhibiting bacterial protein synthesis and promoting antibiotic resistance through horizontal gene transfer and selective pressure. Additionally, the reviews also focus on transition of gut microbiota across different age groups. It also addresses the dysbiotic shift induced by macrolides and its recovery following antibiotic discontinuation. Factors contributing to macrolides resistance, including genetic mutations and environmental factors, are discussed. The focus has been on alternative therapeutic approaches highlighted to mitigate resistance. Overall, the review provides a comprehensive overview of the implications associated with macrolides on gut health and offers insights into managing and minimizing resistance development. gut microbiota antibiotic resistance different age groups analysis črevesne mikrobiote antibiotiki odpornost različne starostne skupine true false true Elsevier Nizozemska Angleški jezik Slovenski jezik © 2025 The Authors. Neznano 2025-12-15 11:42:36 2025-12-15 11:42:37 2025-12-16 03:44:29 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Soavtor Raghuraj Singh Chouhan; Opis vira z dne 9. 6. 2025; 1-15 str. Vol. 24, 100122 Jun. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-07-05 2025-02-06 2025-02-13 579 2590-0978 10.1016/j.medmic.2025.100122 238702083 https://www.sciencedirect.com/science/article/pii/S2590097825000035?via%3Dihub 1 c7a50bf6-d9a2-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36910 RAZ_Shayista_H._2025.pdf RAZ_Shayista_H._2025.pdf 1 699DBEF77359FC31D40162268C8B30D3 4ba85b45c35fc881eb27be079242198a20053f40b4ae3077146a30e62bff5467 852b8f58-d9a4-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36911 Institut Jožef Stefan 0 0 0