| Title: | Prolonged hospitalization signature and early antibiotic effects on the nasopharyngeal resistome in preterm infants |
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| Authors: | ID Dhariwal, Achal (Author)
ID Rajar, Polona (Author)
ID Salvadori, Gabriela (Author)
ID Aarø Åmdal, Heidi (Author)
ID Berild, Dag (Author)
ID Saugstad, Ola Didrik (Author)
ID Fugelseth, Drude (Author)
ID Greisen, Gorm (Author), et al. |
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| Files: |  PDF - Presentation file, download (1,83 MB)
MD5: BC621742F8CF996A682F4C12481EF732
 URL - Source URL, visit https://www.nature.com/articles/s41467-024-50433-7
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Respiratory pathogens, commonly colonizing nasopharynx, are among the leading causes of death due to antimicrobial resistance. Yet, antibiotic resistance determinants within nasopharyngeal microbial communities remain poorly understood. In this prospective cohort study, we investigate the nasopharynx resistome development in preterm infants, assess early antibiotic impact on its trajectory, and explore its association with clinical covariates using shotgun metagenomics. Our findings reveal widespread nasopharyngeal carriage of antibiotic resistance genes (ARGs) with resistomes undergoing transient changes, including increased ARG diversity, abundance, and composition alterations due to early antibiotic exposure. ARGs associated with the critical nosocomial pathogen Serratia marcescens persist up to 8–10 months of age, representing a long-lasting hospitalization signature. The nasopharyngeal resistome strongly correlates with microbiome composition, with inter-individual differences and postnatal age explaining most of the variation. Our report on the collateral effects of antibiotics and prolonged hospitalization underscores the urgency of further studies focused on this relatively unexplored reservoir of pathogens and ARGs. |
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| Keywords: | preterm infants, respiratory resistome, whole genome sequencing, genetics, drug effects |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-13 |
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| Numbering: | Vol. 15, article no. 6024 |
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| PID: | 20.500.12556/DiRROS-24697  |
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| UDC: | 61:575 |
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| ISSN on article: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-50433-7 |
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| COBISS.SI-ID: | 256494851 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 10. 11. 2025;
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| Publication date in DiRROS: | 12.12.2025 |
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| Views: | 56 |
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| Downloads: | 23 |
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| Metadata: |    |
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