| Title: | Systemic auto-inflammatory manifestations in patients with spondyloarthritis |
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| Authors: | ID Gaggiano, Carla (Author)
ID Zajc Avramovič, Mojca (Author)
ID Vitale, Antonio (Author)
ID Emeršič, Nina (Author)
ID Sota, Jurgen (Author)
ID Toplak, Nataša (Author)
ID Gentileschi, Stefano (Author)
ID Caggiano, Valeria (Author)
ID Tarsia, Maria (Author)
ID Markelj, Gašper (Author)
ID Vesel, Tina (Author)
ID Koren Jeverica, Anja (Author)
ID Avčin, Tadej (Author), et al. |
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| Files: |  PDF - Presentation file, download (1,37 MB)
MD5: 87AD95768E8A14E21F47B68919D79C7B
 URL - Source URL, visit https://www.sciencedirect.com/science/article/pii/S1297319X24000836
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Objectives. – (1) characterizing a group of spondyloarthritis (SpA) patients with systemic autoinflammatory symptoms (S-SpA); (2) comparing SpA features with and without auto-inflammatory symptoms; (3) comparing the auto-inflammatory features of S-SpA and Still’s disease (SD). Methods. – Retrospective observational study. Clinical data of adult and pediatric patients with S-SpA, SD or SpA were collected retrospectively and analyzed. Results. – Forty-one subjects with S-SpA, 39 with SD and 42 with SpA were enrolled. The median latency between systemic and articular manifestations in S-SpA was 4.4 (IQR: 7.2) years. S-SpA and SpA had similar frequency of peripheral arthritis and enthesitis (N.S.), while tenosynovitis was more frequent(P = 0.01) and uveitis less frequent (P < 0.01) in S-SpA. MRI showed signs of sacroiliac inflammation and damage in both S-SpA and SpA equally (N.S.). S-SpA patients had less corner inflammatory lesions (P < 0.05) and inflammation at the facet joints (P < 0.01), more interspinous enthesitis (P = 0.01) and inter-apophyseal capsulitis (P < 0.01). Compared to SD, S-SpA patients had lower-grade fever (P < 0.01), less rash (P < 0.01) and weight loss (P < 0.05), but more pharyngitis (P < 0.01), gastrointestinal symptoms (P < 0.01) and chest pain (P < 0.05). ESR, CRP, WBC, ANC, LDH tested higher in SD (P < 0.01). Resolution of systemic symptoms was less frequent in S-SpA than SD on corticosteroid (P < 0.01) and methotrexate (P < 0.05) treatment. When considering all SD patients, a complete response to corticosteroids in the systemic phase significantly reduced the likelihood of developing SpA (OR = 0.06, coefficient −2.87 [CI: −5.0 to −0.8]). Conclusions. – SpA should be actively investigated in patients with auto-inflammatory manifestations, including undifferentiated auto-inflammatory disease and SD |
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| Keywords: | spondyloarthritis, febrile spondyloarthritis, Still’s disease, systemic juvenile idiopathic arthritis, adult-onset Still’s disease, auto-inflammatory diseases |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-10 |
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| Numbering: | Vol. 91, iss. 2, [article no.] 105772 |
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| PID: | 20.500.12556/DiRROS-24654  |
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| UDC: | 616-002 |
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| ISSN on article: | 1297-319X |
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| DOI: | 10.1016/j.jbspin.2024.105772 |
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| COBISS.SI-ID: | 212370947 |
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| Note: |
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| Publication date in DiRROS: | 10.12.2025 |
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| Views: | 62 |
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| Downloads: | 27 |
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