20.500.12556/DiRROS-24654 Systemic auto-inflammatory manifestations in patients with spondyloarthritis Objectives. – (1) characterizing a group of spondyloarthritis (SpA) patients with systemic autoinflammatory symptoms (S-SpA); (2) comparing SpA features with and without auto-inflammatory symptoms; (3) comparing the auto-inflammatory features of S-SpA and Still’s disease (SD). Methods. – Retrospective observational study. Clinical data of adult and pediatric patients with S-SpA, SD or SpA were collected retrospectively and analyzed. Results. – Forty-one subjects with S-SpA, 39 with SD and 42 with SpA were enrolled. The median latency between systemic and articular manifestations in S-SpA was 4.4 (IQR: 7.2) years. S-SpA and SpA had similar frequency of peripheral arthritis and enthesitis (N.S.), while tenosynovitis was more frequent(P = 0.01) and uveitis less frequent (P < 0.01) in S-SpA. MRI showed signs of sacroiliac inflammation and damage in both S-SpA and SpA equally (N.S.). S-SpA patients had less corner inflammatory lesions (P < 0.05) and inflammation at the facet joints (P < 0.01), more interspinous enthesitis (P = 0.01) and inter-apophyseal capsulitis (P < 0.01). Compared to SD, S-SpA patients had lower-grade fever (P < 0.01), less rash (P < 0.01) and weight loss (P < 0.05), but more pharyngitis (P < 0.01), gastrointestinal symptoms (P < 0.01) and chest pain (P < 0.05). ESR, CRP, WBC, ANC, LDH tested higher in SD (P < 0.01). Resolution of systemic symptoms was less frequent in S-SpA than SD on corticosteroid (P < 0.01) and methotrexate (P < 0.05) treatment. When considering all SD patients, a complete response to corticosteroids in the systemic phase significantly reduced the likelihood of developing SpA (OR = 0.06, coefficient −2.87 [CI: −5.0 to −0.8]). Conclusions. – SpA should be actively investigated in patients with auto-inflammatory manifestations, including undifferentiated auto-inflammatory disease and SD spondyloarthritis febrile spondyloarthritis Still’s disease systemic juvenile idiopathic arthritis adult-onset Still’s disease auto-inflammatory diseases true false true Angleški jezik Ni določen Neznano 2025-12-10 13:48:10 2025-12-10 13:48:11 2025-12-11 03:46:38 0000-00-00 00:00:00 2024 0 0 str. 1-10 iss. 2, [article no.] 105772 Vol. 91 2024 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616-002 1297-319X 10.1016/j.jbspin.2024.105772 212370947 RAZ_Gaggiano_Carla_2024.pdf RAZ_Gaggiano_Carla_2024.pdf 1 87AD95768E8A14E21F47B68919D79C7B efc5f5dc9c7d7c5f3ee84063c76f9a1c8462643e6927206a0cc4a41cb8b0a568 aabedb05-d5c6-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36802 https://www.sciencedirect.com/science/article/pii/S1297319X24000836 0 7e8938a7-d5c6-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36801 Univerzitetni klinični center Ljubljana 0 0 0