| Title: | Integrating genetic insights, technological advancements, screening, and personalized pharmacological interventions in childhood obesity |
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| Authors: | ID Šket, Robert (Author)
ID Slapnik, Barbara (Author)
ID Kotnik, Primož (Author)
ID Črepinšek, Klementina (Author)
ID Čugalj Kern, Barbara (Author)
ID Tesovnik, Tine (Author)
ID Jenko Bizjan, Barbara (Author)
ID Vrhovšek, Blaž (Author)
ID Remec, Žiga Iztok (Author)
ID Debeljak, Maruša (Author)
ID Battelino, Tadej (Author)
ID Kovač, Jernej (Author) |
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| Files: |  PDF - Presentation file, download (1,68 MB)
MD5: 28BD1EE776405D499E7B1080519CB9FA
 URL - Source URL, visit https://link.springer.com/article/10.1007/s12325-024-03057-8
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Childhood obesity is a significant global health challenge with rising prevalence over the past 50 years, affecting both immediate and long-term health outcomes. The increase in prevalence from 0.7% to 5.6% in girls and 0.9% to 7.8% in boys highlights the urgency of addressing this epidemic. By 2025, it is estimated that 206 million children and adolescents aged 5–19 years will be living with obesity. This review explores the complex interplay of genomics and genetics in pediatric obesity, transitioning from monogenic and polygenic obesity to epigenetics, and incorporating advancements in omics technologies. The evolutionary purpose of adiposity, systemic evaluation of hyperphagia, and the role of various genetic factors are discussed. Technological advancements in genotyping offer new insights and interventions. The integration of genetic screening into clinical practice for early identification and personalized treatment strategies is emphasized. |
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| Keywords: | hemophilia, wearable, Florio HAEMO, adherence, patient satisfaction |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 72–93 |
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| Numbering: | Vol. 42, iss. 1 |
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| PID: | 20.500.12556/DiRROS-24434  |
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| UDC: | 61 |
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| ISSN on article: | 1865-8652 |
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| DOI: | 10.1007/s12325-024-03057-8 |
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| COBISS.SI-ID: | 220836611 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 3. 1. 2025; |
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| Publication date in DiRROS: | 27.11.2025 |
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| Views: | 115 |
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| Downloads: | 61 |
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