20.500.12556/DiRROS-24434 Integrating genetic insights, technological advancements, screening, and personalized pharmacological interventions in childhood obesity Childhood obesity is a significant global health challenge with rising prevalence over the past 50 years, affecting both immediate and long-term health outcomes. The increase in prevalence from 0.7% to 5.6% in girls and 0.9% to 7.8% in boys highlights the urgency of addressing this epidemic. By 2025, it is estimated that 206 million children and adolescents aged 5–19 years will be living with obesity. This review explores the complex interplay of genomics and genetics in pediatric obesity, transitioning from monogenic and polygenic obesity to epigenetics, and incorporating advancements in omics technologies. The evolutionary purpose of adiposity, systemic evaluation of hyperphagia, and the role of various genetic factors are discussed. Technological advancements in genotyping offer new insights and interventions. The integration of genetic screening into clinical practice for early identification and personalized treatment strategies is emphasized. hemophilia wearable Florio HAEMO adherence patient satisfaction true false true Angleški jezik Ni določen Neznano 2025-11-27 12:49:27 2025-11-27 12:49:27 2025-11-28 03:40:50 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 3. 1. 2025; str. 72–93 iss. 1 Vol. 42 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 61 1865-8652 10.1007/s12325-024-03057-8 220836611 RAZ_Sket_Robert_2025.pdf RAZ_Sket_Robert_2025.pdf 1 28BD1EE776405D499E7B1080519CB9FA c7dfca807e36d349b89f10c82e07c73a40b87c5ba0efb67d161dde6391b087e8 b949724b-cb8b-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36387 https://link.springer.com/article/10.1007/s12325-024-03057-8 1 2433d146-cb87-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36386 Univerzitetni klinični center Ljubljana 0 0 0