| Title: | Association of tumor-infiltrating lymphocytes and inflammation status with survival outcome in patients with high-grade serous ovarian carcinoma |
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| Authors: | ID Miceska, Simona (Author)
ID Grašič-Kuhar, Cvetka (Author)
ID Frković-Grazio, Snježana (Author)
ID Škof, Erik (Author)
ID Krishnamoorthy, Praveen (Author)
ID Khabele, Dineo (Author)
ID Kloboves-Prevodnik, Veronika (Author) |
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| Files: |  URL - Source URL, visit https://www.mdpi.com/2072-6694/17/14/2269
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  OI - Institute of Oncology
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| Abstract: | In this study, we investigated the association between tumor-infiltrating lymphocytes (TILs), inflammation status, and progression-free survival (PFS) in patients with primary high-grade serous ovarian carcinoma (HGSC). We assessed the percentages of different intraepithelial and stromal TIL subtypes using both manual and digital methods, following established recommendations for TIL assessment. In addition, we evaluated inflammation status through several immune scores, including the pan-immune-inflammation value (PIV). Our results suggest that stromal CD3+ and CD8+ TILs, as well as PIV, may serve as potential prognostic indicators in HGSC, as they remained potential independent markers in multivariate analysis. |
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| Keywords: | ovarian carcinoma, high-grade serous ovarian carcinoma, prognostic factors |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 26.05.2025 |
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| Article acceptance date: | 05.07.2025 |
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| Publication date: | 08.07.2025 |
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| Place of publishing: | Basel |
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| Publisher: | MDPI, Basel, Switzerland |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 2269-1-2269-21 |
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| Numbering: | Vol. 17, no. 4 |
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| Source: | Basel, Switzerland |
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| PID: | 20.500.12556/DiRROS-24412  |
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| UDC: | 618.1 |
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| ISSN on article: | 2072-6694 |
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| DOI: | 10.3390/cancers17142269 |
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| COBISS.SI-ID: | 241873923 |
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| Copyright: | by Authors |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 9. 7. 2025;
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| Publication date in DiRROS: | 05.12.2025 |
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| Views: | 63 |
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| Downloads: | 22 |
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| Metadata: |    |
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