| Title: | Effect of tirzepatide-induced weight loss on adipose tissue in obesity : rationale and design of the randomized placebo-controlled Tirzepatide Brown and Beige Adipose Tissue Activation (TABFAT) trial |
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| Authors: | ID Herman, Rok (Author)
ID Jensterle Sever, Mojca (Author)
ID Horvat, Simon (Author)
ID Ležaič, Luka (Author)
ID Snoj, Žiga (Author)
ID Pušnik, Igor (Author)
ID Goričar, Katja (Author)
ID Cör, Andrej (Author)
ID Pušnik, Luka (Author)
ID Mlačnik, Vid (Author)
ID Hanželič, Lara (Author)
ID Janež, Andrej (Author) |
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| Files: |  PDF - Presentation file, download (1003,47 KB)
MD5: DD09720095FA8C60E680F8A5C1908DD1
 URL - Source URL, visit https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-025-09045-9
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background Obesity is a complex disease marked by excessive, dysfunctional adipose tissue accumulation. Recent research underscores the pivotal role of brown adipose tissue (BAT) in metabolic health and its potential as a thera- peutic target for obesity management. Emerging preclinical and clinical evidence suggests that second-generation anti-obesity drugs, especially dual agonists such as tirzepatide, may enhance BAT activity. Additionally, beige adipose tissue, derived from white adipose tissue (WAT), may contribute significantly to whole-body thermogenesis, yet its role remains underexplored. Methods This investigator-initiated, randomized, placebo-controlled clinical trial aims to evaluate the effects of tirzepatide on BAT activity and WAT browning in premenopausal women with obesity. Thirty-four participants will be randomized 1:1 to receive either tirzepatide or a placebo for 24 weeks. Primary outcomes include changes in BAT volume and activity, assessed using 18F-FDG-PET/CT, MRI, and infrared thermography, as well as the induction of WAT browning, evaluated through changes in mRNA expression patterns and histomorphometric alterations in subcuta- neous adipose tissue samples. Secondary outcomes will involve the assessment of whole-body composition, resting energy expenditure, and various metabolic health markers, correlated with thermogenic adipose tissue changes. Comparative analysis of BAT assessment methods will refine protocols for research and clinical use. Discussion This study is the first to systematically explore the potential of pharmacological obesity management to enhance BAT activity and induce WAT browning. Results may establish thermogenic adipose tissue augmentation as a novel mechanism of action for second-generation anti-obesity medications. |
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| Keywords: | brown adipose tissue, beige adipose tissue, pancreas resection, tirzepatide, obesity |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 1-20 |
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| Numbering: | Vol. 26, issue 1, [article no.] 300 |
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| PID: | 20.500.12556/DiRROS-24380  |
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| UDC: | 616.4 |
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| ISSN on article: | 1745-6215 |
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| DOI: | 10.1186/s13063-025-09045-9 |
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| COBISS.SI-ID: | 246428675 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 24. 8. 2025;
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| Publication date in DiRROS: | 26.11.2025 |
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| Views: | 121 |
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| Downloads: | 73 |
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