| Title: | Cysteine cathepsins as therapeutic targets in immune regulation and immune disorders |
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| Authors: | ID Senjor, Emanuela, Institut "Jožef Stefan" (Author)
ID Kos, Janko, Institut "Jožef Stefan" (Author)
ID Perišić, Milica, Institut "Jožef Stefan" (Author) |
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| Files: |  URL - Source URL, visit https://www.mdpi.com/2227-9059/11/2/476
 PDF - Presentation file, download (7,45 MB)
MD5: 226242066F679F1A4D707D4F138474D0
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  IJS - Jožef Stefan Institute
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| Abstract: | Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital role in several processes—such as protein degradation, changes in cell signaling, cell morphology, migration and proliferation, and energy metabolism. In addition to their lysosomal function, they are also secreted and may remain functional in the extracellular space. Upregulation of cathepsin expression is associated with several pathological conditions including cancer, neurodegeneration, and immune-system dysregulation. In this review, we present an overview of cysteine-cathepsin involvement and possible targeting options for mitigation of aberrant function in immune disorders such as inflammation, autoimmune diseases, and immune response in cancer. |
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| Keywords: | cysteine cathepsins, inflammation, autoimmune diseases, cancer |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 31.12.2022 |
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| Article acceptance date: | 02.02.2023 |
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| Publication date: | 07.02.2023 |
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| Publisher: | MDPI |
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| Year of publishing: | 2023 |
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| Number of pages: | str. 1-17 |
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| Numbering: | Vol. 11, iss. 2, [article] no. 476 |
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| Source: | Švica |
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| PID: | 20.500.12556/DiRROS-23486  |
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| UDC: | 543.2/.9 |
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| ISSN on article: | 2227-9059 |
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| DOI: | 10.3390/biomedicines11020476 |
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| COBISS.SI-ID: | 141804547 |
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| Copyright: | © 2023 by the authors. |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 15. 2. 2023;
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| Publication date in DiRROS: | 04.09.2025 |
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| Views: | 370 |
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| Downloads: | 179 |
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