20.500.12556/DiRROS-23486 Cysteine cathepsins as therapeutic targets in immune regulation and immune disorders Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital role in several processes—such as protein degradation, changes in cell signaling, cell morphology, migration and proliferation, and energy metabolism. In addition to their lysosomal function, they are also secreted and may remain functional in the extracellular space. Upregulation of cathepsin expression is associated with several pathological conditions including cancer, neurodegeneration, and immune-system dysregulation. In this review, we present an overview of cysteine-cathepsin involvement and possible targeting options for mitigation of aberrant function in immune disorders such as inflammation, autoimmune diseases, and immune response in cancer. cysteine cathepsins inflammation autoimmune diseases cancer cisteinski katepsini true false true MDPI Švica Angleški jezik Slovenski jezik © 2023 by the authors. Neznano 2025-09-04 11:27:00 2025-09-04 11:27:01 2025-10-24 03:54:25 0000-00-00 00:00:00 2023 0 0 Nasl. z nasl. zaslona; Opis vira z dne 15. 2. 2023; str. 1-17 iss. 2, [article] no. 476 Vol. 11 Feb. 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2022-12-31 2023-02-02 2023-02-07 543.2/.9 2227-9059 10.3390/biomedicines11020476 141804547 https://www.mdpi.com/2227-9059/11/2/476 1 51ca3cc2-8971-11f0-9bb7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=34736 RAZ_Senjor_Emanuela_2023.pdf RAZ_Senjor_Emanuela_2023.pdf 1 226242066F679F1A4D707D4F138474D0 fc1776949ce38f6992a6b8b5d0d4792b9a11b12a91d7333c15b189d9ffe4a446 914087ad-8982-11f0-9bb7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=34737 Institut Jožef Stefan 0 0 0