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Title:Editorial : The role of immune cells in the progression of autoimmune diseases affecting the CNS
Authors:ID Kowal, Czeslawa (Author)
ID Pohar, Jelka (Author)
ID Zavala, Flora (Author)
Files:URL URL - Source URL, visit https://doi.org/10.3389/fimmu.2022.1078396
 
.pdf PDF - Presentation file, download (296,08 KB)
MD5: EA7E27988E82BF86C1644A0F122656BD
 
Language:English
Typology:1.03 - Other scientific articles
Organization:Logo NIB - National Institute of Biology
Abstract:Insights into the dynamics of immune responses in immune-privileged tissues such as the central nervous system (CNS) are critical to understanding the etiology of autoimmune diseases. Essential in this field is understanding the ways immune cells access and traffic across different types of the blood-brain barrier (BBB), and how the therapeutics alter these processes (see excellent review by Mapunda et al.). The current Research Topic brought into attention a diverse panel of original research papers and two reviews on the immune cells involved in CNS pathophysiology, including dendritic cells (DC), mucosal-associated invariant T (MAIT) cells, neutrophils, and pathogenic Th17 cells, as well as a different aspects of that pathophysiology, including molecular signaling pathways (PP2Cδ) and the role of signaling complexes, known as supramolecular organizing centers (SMOCs), therapeutic interventions (STAT3-specific nanobody, treatment of rheumatoid meningitis with intravenous immunoglobulin - IVIg), possible new forms of autoantigens (neutrophil extracellular traps (NETs) in neuropsychiatric systemic lupus erythematosus - NPSLE), and assessment of correlation between inflammatory markers and severity of autoimmune encephalitis (AE).
Keywords:CNS pathophysiology, dendritic cells, mucosal-associated invariant T cells, STAT3, Th17 cells, PP2Cδ, supramolecular organizing centers (SMOCs), neutrophil extracellular traps, cytology
Publication status:Published
Publication version:Version of Record
Publication date:09.11.2022
Year of publishing:2022
Number of pages:str. 1-3
Numbering:Vol. 13
PID:20.500.12556/DiRROS-20158 New window
UDC:576
ISSN on article:1664-3224
DOI:10.3389/fimmu.2022.1078396 New window
COBISS.SI-ID:131046403 New window
Note:Nasl. z nasl. zaslona; Opis vira z dne 25. 11. 2022;
Publication date in DiRROS:06.08.2024
Views:447
Downloads:200
Metadata:XML DC-XML DC-RDF
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KOWAL, Czeslawa, POHAR, Jelka and ZAVALA, Flora, 2022, Editorial : The role of immune cells in the progression of autoimmune diseases affecting the CNS. Frontiers in immunology [online]. 2022. Vol. 13, p. 1–3. [Accessed 21 April 2025]. DOI 10.3389/fimmu.2022.1078396. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=20158
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Record is a part of a journal

Title:Frontiers in immunology
Shortened title:Front. immunol.
Publisher:Frontiers Research Foundation
ISSN:1664-3224
COBISS.SI-ID:30774233 New window

Document is financed by a project

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0245-2019
Name:Ekotoksiologija, toksikološka genomika in karcinogeneza
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:J3-3084-2021
Name:Inducibilno Programiranje Intrinzičnih Lastnosti Celic CAR T za Imunoterapijo Raka
Funder:NIH - National Institutes of Health
Project number:1P01 AI073693-06

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Language:Slovenian
Keywords:patofiziologija osrednjega živčevja, avtoimunske bolezni, terapije, imunske celice, prirojena imunost, pridobljena imunost, citologija


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