20.500.12556/DiRROS-20158 Editorial The role of immune cells in the progression of autoimmune diseases affecting the CNS Insights into the dynamics of immune responses in immune-privileged tissues such as the central nervous system (CNS) are critical to understanding the etiology of autoimmune diseases. Essential in this field is understanding the ways immune cells access and traffic across different types of the blood-brain barrier (BBB), and how the therapeutics alter these processes (see excellent review by Mapunda et al.). The current Research Topic brought into attention a diverse panel of original research papers and two reviews on the immune cells involved in CNS pathophysiology, including dendritic cells (DC), mucosal-associated invariant T (MAIT) cells, neutrophils, and pathogenic Th17 cells, as well as a different aspects of that pathophysiology, including molecular signaling pathways (PP2Cδ) and the role of signaling complexes, known as supramolecular organizing centers (SMOCs), therapeutic interventions (STAT3-specific nanobody, treatment of rheumatoid meningitis with intravenous immunoglobulin - IVIg), possible new forms of autoantigens (neutrophil extracellular traps (NETs) in neuropsychiatric systemic lupus erythematosus - NPSLE), and assessment of correlation between inflammatory markers and severity of autoimmune encephalitis (AE). CNS pathophysiology dendritic cells mucosal-associated invariant T cells STAT3 Th17 cells PP2Cδ supramolecular organizing centers (SMOCs) neutrophil extracellular traps cytology patofiziologija osrednjega živčevja avtoimunske bolezni terapije imunske celice prirojena imunost pridobljena imunost citologija true false true Angleški jezik Slovenski jezik Neznano 2024-08-06 14:57:49 2024-08-06 14:57:49 2024-08-07 04:07:29 0000-00-00 00:00:00 2022 0 0 Nasl. z nasl. zaslona; Opis vira z dne 25. 11. 2022; str. 1-3 Vol. 13 Nov. 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2022-11-09 576 1664-3224 10.3389/fimmu.2022.1078396 131046403 https://doi.org/10.3389/fimmu.2022.1078396 1 c42ced65-53e2-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28161 RAZ_Kowal_Czeslawa_2022.pdf RAZ_Kowal_Czeslawa_2022.pdf 1 EA7E27988E82BF86C1644A0F122656BD 2ba40f8a50f75cb8df977b06a4102eb634dcbb257e9a456e4a5306b3ea191555 f847cc04-53e2-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28162 Nacionalni inštitut za biologijo 0 0 0