| Title: | Angiogenesis in gynecological cancers and the options for anti-angiogenesis therapy |
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| Authors: | ID Yetkin-Arik, Bahar (Author)
ID Kastelein, Arnoud W. (Author)
ID Klaassen, Ingeborg (Author)
ID Jansen, Charlotte H. J. R. (Author)
ID Latul, Yani P. (Author)
ID Vittori, Miloš (Author)
ID Biri, Aydan (Author)
ID Kahraman, Korhan (Author)
ID Griffioen, Arjan W. (Author)
ID Amant, Frederic (Author)
ID Lok, Christianne A. R. (Author)
ID Schlingemann, Reinier O. (Author)
ID Noorden, Cornelis J. F. van (Author) |
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| Files: |  PDF - Presentation file, download (5,60 MB)
MD5: 55B1FFCCD2678A8446B7D83A6E818B2B
 URL - Source URL, visit https://doi.org/10.1016/j.bbcan.2020.188446
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  NIB - National Institute of Biology
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| Abstract: | Angiogenesis is required in cancer, including gynecological cancers, for the growth of primary tumors and secondary metastases. Development of anti-angiogenesis therapy in gynecological cancers and improvement of its efficacy have been a major focus of fundamental and clinical research. However, survival benefits of current anti-angiogenic agents, such as bevacizumab, in patients with gynecological cancer, are modest. Therefore, a better understanding of angiogenesis and the tumor microenvironment in gynecological cancers is urgently needed to develop more effective anti-angiogenic therapies, either or not in combination with other therapeutic approaches. We describe the molecular aspects of (tumor) blood vessel formation and the tumor microenvironment and provide an extensive clinical overview of current anti-angiogenic therapies for gynecological cancers. We discuss the different phenotypes of angiogenic endothelial cells as potential therapeutic targets, strategies aimed at intervention in their metabolism, and approaches targeting their (inflammatory) tumor microenvironment. |
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| Keywords: | angiogenesis, anti-angiogenic therapy, endothelial cells, endothelial cell metabolism, gynecological cancer, non-tip cells, tip cells, tumor microenvironment, vascular disrupting agents |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.01.2021 |
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| Year of publishing: | 2021 |
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| Number of pages: | str. 1-18 |
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| Numbering: | iss. 1, 188446 |
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| PID: | 20.500.12556/DiRROS-20105  |
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| UDC: | 577 |
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| ISSN on article: | 0304-419X |
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| DOI: | 10.1016/j.bbcan.2020.188446 |
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| COBISS.SI-ID: | 35856899 |
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| Publication date in DiRROS: | 05.08.2024 |
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| Views: | 315 |
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| Downloads: | 231 |
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