| Naslov: | Angiogenesis in gynecological cancers and the options for anti-angiogenesis therapy |
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| Avtorji: | ID Yetkin-Arik, Bahar (Avtor)
ID Kastelein, Arnoud W. (Avtor)
ID Klaassen, Ingeborg (Avtor)
ID Jansen, Charlotte H. J. R. (Avtor)
ID Latul, Yani P. (Avtor)
ID Vittori, Miloš (Avtor)
ID Biri, Aydan (Avtor)
ID Kahraman, Korhan (Avtor)
ID Griffioen, Arjan W. (Avtor)
ID Amant, Frederic (Avtor)
ID Lok, Christianne A. R. (Avtor)
ID Schlingemann, Reinier O. (Avtor)
ID Noorden, Cornelis J. F. van (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (5,60 MB)
MD5: 55B1FFCCD2678A8446B7D83A6E818B2B
 URL - Izvorni URL, za dostop obiščite https://doi.org/10.1016/j.bbcan.2020.188446
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.02 - Pregledni znanstveni članek |
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| Organizacija: |  NIB - Nacionalni inštitut za biologijo
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| Povzetek: | Angiogenesis is required in cancer, including gynecological cancers, for the growth of primary tumors and secondary metastases. Development of anti-angiogenesis therapy in gynecological cancers and improvement of its efficacy have been a major focus of fundamental and clinical research. However, survival benefits of current anti-angiogenic agents, such as bevacizumab, in patients with gynecological cancer, are modest. Therefore, a better understanding of angiogenesis and the tumor microenvironment in gynecological cancers is urgently needed to develop more effective anti-angiogenic therapies, either or not in combination with other therapeutic approaches. We describe the molecular aspects of (tumor) blood vessel formation and the tumor microenvironment and provide an extensive clinical overview of current anti-angiogenic therapies for gynecological cancers. We discuss the different phenotypes of angiogenic endothelial cells as potential therapeutic targets, strategies aimed at intervention in their metabolism, and approaches targeting their (inflammatory) tumor microenvironment. |
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| Ključne besede: | angiogenesis, anti-angiogenic therapy, endothelial cells, endothelial cell metabolism, gynecological cancer, non-tip cells, tip cells, tumor microenvironment, vascular disrupting agents |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 01.01.2021 |
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| Leto izida: | 2021 |
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| Št. strani: | str. 1-18 |
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| Številčenje: | iss. 1, 188446 |
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| PID: | 20.500.12556/DiRROS-20105  |
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| UDK: | 577 |
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| ISSN pri članku: | 0304-419X |
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| DOI: | 10.1016/j.bbcan.2020.188446 |
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| COBISS.SI-ID: | 35856899 |
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| Datum objave v DiRROS: | 05.08.2024 |
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| Število ogledov: | 318 |
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| Število prenosov: | 232 |
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| Metapodatki: |    |
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