| Title: | PD-L1 expression in squamous-cell carcinoma and adenocarcinoma of the lung |
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| Authors: | ID Janžič, Urška (Author)
ID Kern, Izidor (Author)
ID Janžič, Andrej (Author)
ID Čavka, Luka (Author)
ID Čufer, Tanja (Author) |
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| Files: |  URL - Source URL, visit https://www.degruyter.com/downloadpdf/j/raon.2017.51.issue-3/raon-2017-0037/raon-2017-0037.pdf
URL - Source URL, visit https://www.degruyter.com/view/j/raon.2017.51.issue-3/raon-2017-0037/raon-2017-0037.xml
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MD5: 6537F7C50DB083FDA8A916970261F1CC
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  OI - Institute of Oncology
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| Abstract: | With introduction of immunotherapy (IT) into the treatment of advanced non-small-cell lung cancer (NSCLC), a need for predictive biomarker became apparent. Programmed death ligand 1 (PD-L1) protein expression is most widely explored predictive marker for response to IT. We assessed PD-L1 expression in tumor cells (TC) and immune cells (IC) of squamous-cell carcinoma (SCC) and adenocarcinoma (AC) patients. We obtained 54 surgically resected tumor specimens and assessed PD-L1 expression by immunohistochemistry after staining them with antibody SP142 (Ventana, USA). Clinicopathological characteristics were acquired from the hospital registry database. Results were analyzed according to cut-off values of % 5% and % 10% of PD-L1 expression on either TC or IC. 29 (54%) samples were AC and 25 (46%) were SCC. PD-L1 expression was significantly higher in TC of SCC compared to AC at both cut-off values (52% vs. 17%, p = 0.016 and 52% vs. 14%, p = 0.007, respectively) no difference in PD-L1 expression in IC of SCC and AC was found. In AC alone, PD-L1 expression was significantly higher in IC compared to TC at both cut-off values (72% vs. 17%, p < 0.001 and 41% vs. 14%, p = 0.008, respectively), while no significant difference between IC and TC PD-L1 expression was revealed in SCC. Our results suggest a significantly higher PD-L1 expression in TC of SCC compared to AC, regardless of the cut-off value. PD-L1 expression in IC is high in both histological subtypes of NSCLC, and adds significantly to the overall positivity of AC but not SCC. |
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| Keywords: | lung cancer, squamous-cell lung cancer, adenocarcinoma, tumor cells, immune cells, PD-L1 expression |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.01.2017 |
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| Publisher: | Association of Radiology and Oncology |
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| Year of publishing: | 2017 |
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| Number of pages: | str. 357-362, XI |
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| Numbering: | Vol. 51, no. 3 |
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| Source: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-19022  |
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| UDC: | 616-006.6:615.37 |
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| ISSN on article: | 1318-2099 |
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| DOI: | 10.1515/raon-2017-0037 |
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| COBISS.SI-ID: | 4381553 |
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| Copyright: | by Authors |
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| Publication date in DiRROS: | 31.05.2024 |
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| Views: | 105 |
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| Downloads: | 89 |
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