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Title:PD-L1 expression in squamous-cell carcinoma and adenocarcinoma of the lung
Authors:ID Janžič, Urška (Author)
ID Kern, Izidor (Author)
ID Janžič, Andrej (Author)
ID Čavka, Luka (Author)
ID Čufer, Tanja (Author)
Files:URL URL - Source URL, visit https://www.degruyter.com/view/j/raon.2017.51.issue-3/raon-2017-0037/raon-2017-0037.xml
 
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MD5: 6537F7C50DB083FDA8A916970261F1CC
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:With introduction of immunotherapy (IT) into the treatment of advanced non-small-cell lung cancer (NSCLC), a need for predictive biomarker became apparent. Programmed death ligand 1 (PD-L1) protein expression is most widely explored predictive marker for response to IT. We assessed PD-L1 expression in tumor cells (TC) and immune cells (IC) of squamous-cell carcinoma (SCC) and adenocarcinoma (AC) patients. We obtained 54 surgically resected tumor specimens and assessed PD-L1 expression by immunohistochemistry after staining them with antibody SP142 (Ventana, USA). Clinicopathological characteristics were acquired from the hospital registry database. Results were analyzed according to cut-off values of % 5% and % 10% of PD-L1 expression on either TC or IC. 29 (54%) samples were AC and 25 (46%) were SCC. PD-L1 expression was significantly higher in TC of SCC compared to AC at both cut-off values (52% vs. 17%, p = 0.016 and 52% vs. 14%, p = 0.007, respectively) no difference in PD-L1 expression in IC of SCC and AC was found. In AC alone, PD-L1 expression was significantly higher in IC compared to TC at both cut-off values (72% vs. 17%, p < 0.001 and 41% vs. 14%, p = 0.008, respectively), while no significant difference between IC and TC PD-L1 expression was revealed in SCC. Our results suggest a significantly higher PD-L1 expression in TC of SCC compared to AC, regardless of the cut-off value. PD-L1 expression in IC is high in both histological subtypes of NSCLC, and adds significantly to the overall positivity of AC but not SCC.
Keywords:lung cancer, squamous-cell lung cancer, adenocarcinoma, tumor cells, immune cells, PD-L1 expression
Publication status:Published
Publication version:Version of Record
Publication date:01.01.2017
Publisher:Association of Radiology and Oncology
Year of publishing:2017
Number of pages:str. 357-362, XI
Numbering:Vol. 51, no. 3
Source:Ljubljana
PID:20.500.12556/DiRROS-19022 New window
UDC:616-006.6:615.37
ISSN on article:1318-2099
DOI:10.1515/raon-2017-0037 New window
COBISS.SI-ID:4381553 New window
Copyright:by Authors
Publication date in DiRROS:31.05.2024
Views:725
Downloads:500
Metadata:XML DC-XML DC-RDF
:
JANŽIČ, Urška, KERN, Izidor, JANŽIČ, Andrej, ČAVKA, Luka and ČUFER, Tanja, 2017, PD-L1 expression in squamous-cell carcinoma and adenocarcinoma of the lung. Radiology and oncology [online]. 2017. Vol. 51, no. 3, p. 357–362, xi. [Accessed 6 April 2025]. DOI 10.1515/raon-2017-0037. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=19022
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

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