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Naslov:PD-L1 expression in squamous-cell carcinoma and adenocarcinoma of the lung
Avtorji:ID Janžič, Urška (Avtor)
ID Kern, Izidor (Avtor)
ID Janžič, Andrej (Avtor)
ID Čavka, Luka (Avtor)
ID Čufer, Tanja (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://www.degruyter.com/view/j/raon.2017.51.issue-3/raon-2017-0037/raon-2017-0037.xml
 
URL URL - Izvorni URL, za dostop obiščite https://www.degruyter.com/downloadpdf/j/raon.2017.51.issue-3/raon-2017-0037/raon-2017-0037.pdf
 
.pdf PDF - Predstavitvena datoteka, prenos (644,78 KB)
MD5: 6537F7C50DB083FDA8A916970261F1CC
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo OI - Onkološki inštitut Ljubljana
Povzetek:With introduction of immunotherapy (IT) into the treatment of advanced non-small-cell lung cancer (NSCLC), a need for predictive biomarker became apparent. Programmed death ligand 1 (PD-L1) protein expression is most widely explored predictive marker for response to IT. We assessed PD-L1 expression in tumor cells (TC) and immune cells (IC) of squamous-cell carcinoma (SCC) and adenocarcinoma (AC) patients. We obtained 54 surgically resected tumor specimens and assessed PD-L1 expression by immunohistochemistry after staining them with antibody SP142 (Ventana, USA). Clinicopathological characteristics were acquired from the hospital registry database. Results were analyzed according to cut-off values of % 5% and % 10% of PD-L1 expression on either TC or IC. 29 (54%) samples were AC and 25 (46%) were SCC. PD-L1 expression was significantly higher in TC of SCC compared to AC at both cut-off values (52% vs. 17%, p = 0.016 and 52% vs. 14%, p = 0.007, respectively) no difference in PD-L1 expression in IC of SCC and AC was found. In AC alone, PD-L1 expression was significantly higher in IC compared to TC at both cut-off values (72% vs. 17%, p < 0.001 and 41% vs. 14%, p = 0.008, respectively), while no significant difference between IC and TC PD-L1 expression was revealed in SCC. Our results suggest a significantly higher PD-L1 expression in TC of SCC compared to AC, regardless of the cut-off value. PD-L1 expression in IC is high in both histological subtypes of NSCLC, and adds significantly to the overall positivity of AC but not SCC.
Ključne besede:lung cancer, squamous-cell lung cancer, adenocarcinoma, tumor cells, immune cells, PD-L1 expression
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.01.2017
Založnik:Association of Radiology and Oncology
Leto izida:2017
Št. strani:str. 357-362, XI
Številčenje:Vol. 51, no. 3
Izvor:Ljubljana
PID:20.500.12556/DiRROS-19022 Novo okno
UDK:616-006.6:615.37
ISSN pri članku:1318-2099
DOI:10.1515/raon-2017-0037 Novo okno
COBISS.SI-ID:4381553 Novo okno
Avtorske pravice:by Authors
Datum objave v DiRROS:31.05.2024
Število ogledov:737
Število prenosov:509
Metapodatki:XML DC-XML DC-RDF
:
JANŽIČ, Urška, KERN, Izidor, JANŽIČ, Andrej, ČAVKA, Luka in ČUFER, Tanja, 2017, PD-L1 expression in squamous-cell carcinoma and adenocarcinoma of the lung. Radiology and oncology [na spletu]. 2017. Vol. 51, no. 3, p. 357–362, xi. [Dostopano 12 april 2025]. DOI 10.1515/raon-2017-0037. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=19022
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Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

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