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Title:Genotoxicity and heating performance of VxFe3-xO4 nanoparticles in health applications
Authors:ID Sanz-Sagué, Beatriz (Author)
ID Sáenz-Hernández, Amaia (Author)
ID Žegura, Bojana (Author)
ID Štern, Alja (Author)
ID Kološa, Katja (Author)
ID Rozman, Iza (Author)
Files:URL URL - Source URL, visit https://doi.org/10.1016/j.cbi.2024.110977
 
.pdf PDF - Presentation file, download (8,91 MB)
MD5: 4D926F6E26809354A5A80AE33B6BEE21
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo NIB - National Institute of Biology
Abstract:The applications of magnetic nanoparticles (MNPs) as biocatalysts in different biomedical areas have been evolved very recently. One of the main challenges in this field is to design affective MNPs surfaces with catalytically active atomic centres, while producing minimal toxicological side effects on the hosting cell or tissues. MNPs of vanadium spinel ferrite (VFe2O4) are a promising material for mimicking the action of natural enzymes in degrading harmful substrates due to the presence of active V5+ centres. However, the toxicity of this material has not been yet studied in detail enough to grant biomedical safety. In this work, we have extensively measured the structural, compositional, and magnetic properties of a series of VxFe3-xO4 spinel ferrite MNPs to assess the surface composition and oxidation state of V atoms, and also performed systematic and extensive in vitro cytotoxicity and genotoxicity testing required to assess their safety in potential clinical applications. We could establish the presence of V5+ at the particle surface even in water-based colloidal samples at pH 7, as well as different amounts of V2+ and V3+ substitution at the A and B sites of the spinel structure. All samples showed large heating efficiency with Specific Loss Power values up to 400 W/g (H0 = 30 kA/m; f = 700 kHz). Samples analysed for safety in human hepatocellular carcinoma (HepG2) cell line with up to 24h of exposure showed that these MNPs did not induce major genomic abnormalities such as micronuclei, nuclear buds, or nucleoplasmic bridges (MNIs, NBUDs, and NPBs), nor did they cause DNA double-strand breaks (DSBs) or aneugenic effects—types of damage considered most harmful to cellular genetic material. The present study is an essential step towards the use of these type of nanomaterials in any biomedical or clinical application.
Keywords:magnetic nanoparticles, vanadium ferrite, cytotoxicity, genotoxicity, specific power absorption, cell viability
Publication status:Published
Publication version:Version of Record
Publication date:24.03.2024
Year of publishing:2024
Number of pages:str. [1]-13
Numbering:Vol. 394, [art. no.] ǂ110977
PID:20.500.12556/DiRROS-18982 New window
UDC:577
ISSN on article:0009-2797
DOI:10.1016/j.cbi.2024.110977 New window
COBISS.SI-ID:190594819 New window
Note:Soavtorji: Amaia Sáenz- Hernández, A. C. Moreno Maldonado, Jesús A. Fuentes-García, Jorge M. Nuñez, Bojana Žegura, Alja Štern, Katja Kološa, Iza Rozman, Teobaldo E. Torres, Gerardo F. Goya;
Publication date in DiRROS:23.05.2024
Views:130
Downloads:147
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Record is a part of a journal

Title:Chemico-biological interactions
Shortened title:Chem.-biol. interact.
Publisher:Elsevier
ISSN:0009-2797
COBISS.SI-ID:1720335 New window

Document is financed by a project

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0245-2019
Name:Ekotoksiologija, toksikološka genomika in karcinogeneza

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:J1-4395-2022
Name:Razvoj novih večfunkcionalnih nanocimov na osnovi kovinskih oksidov in njihova toksikološka karakterizacija (NaNoZymSafe)

Funder:Other - Other funder or multiple funders
Funding programme:European Union-Next GenerationEU
Project number:MCIN/AEI/10.13039/501100011033
Name:MICRODIAL
Acronym:PDC2021-121 409

Funder:EC - European Commission
Funding programme:H2020-MSCA
Project number:101007629
Name:NESTOR project

Funder:EC - European Commission
Funding programme:CutCancer project
Project number:101079113

Funder:ARIS - Slovenian Research and Innovation Agency
Funding programme:Young researchers

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Language:Slovenian
Keywords:magnetni nanodelci, vanadijev ferit, citotoksičnost, genotoksičnost, specifična absorpcijska moč, celična živost


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