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Title:Obstructive urination problems after high-dose-rate brachytherapy boost treatment for prostate cancer are avoidable
Authors:ID Kragelj, Borut (Author)
Files:URL URL - Source URL, visit http://www.degruyter.com/view/j/raon.2016.50.issue-1/raon-2015-0010/raon-2015-0010.xml?format=INT
 
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Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Aiming at improving treatment individualization in patients with prostate cancer treated with combination of external beam radiotherapy and high-dose-rate brachytherapy to boost the dose to prostate (HDRB-B), the objective was to evaluate factors that have potential impact on obstructive urination problems (OUP) after HDRB-B. Patients and methods. In the follow-up study 88 patients consecutively treated with HDRB-B at the Institute of Oncology Ljubljana in the period 2006-2011 were included. The observed outcome was deterioration of OUP (DOUP) during the follow-up period longer than 1 year. Univariate and multivariate relationship analysis between DOUP and potential risk factors (treatment factors, patients% characteristics) was carried out by using binary logistic regression. ROC curve was constructed on predicted values and the area under the curve (AUC) calculated to assess the performance of the multivariate model. Results. Analysis was carried out on 71 patients who completed 3 years of follow-up. DOUP was noted in 13/71 (18.3%) of them. The results of multivariate analysis showed statistically significant relationship between DOUP and anticoagulation treatment (OR 4.86, 95% C.I. limits: 1.21-19.61, p = 0.026). Also minimal dose received by 90% of the urethra volume was close to statistical significance (OR = 1.23; 95% C.I. limits: 0.98-1.07, p = 0.099). The value of AUC was 0.755. Conclusions. The study emphasized the relationship between DOUP and anticoagulation treatment, and suggested the multivariate model with fair predictive performance. This model potentially enables a reduction of DOUP after HDRB-B. It supports the belief that further research should be focused on urethral sphincter as a critical structure for OUP.
Keywords:prostate cancer, high-dose-rate brachytherapy boost, urinary stricture, obstructive urination problems
Publication status:Published
Publication version:Version of Record
Publication date:01.03.2016
Publisher:Association of Radiology and Oncology
Year of publishing:2016
Number of pages:str. 94-103, VII
Numbering:Vol. 50, no. 1
Source:Ljubljana
PID:20.500.12556/DiRROS-18858 New window
UDC:616.65-006-08
ISSN on article:1318-2099
DOI:10.1515/raon-2015-0010 New window
COBISS.SI-ID:2275707 New window
Copyright:by Authors
Publication date in DiRROS:30.04.2024
Views:517
Downloads:254
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Keywords:prostata, rak (medicina), brahiradioterapija, obsevanje, obstruktivne težave, urinarni sistem


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