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Naslov:Obstructive urination problems after high-dose-rate brachytherapy boost treatment for prostate cancer are avoidable
Avtorji:ID Kragelj, Borut (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite http://www.degruyter.com/view/j/raon.2016.50.issue-1/raon-2015-0010/raon-2015-0010.xml?format=INT
 
.pdf PDF - Predstavitvena datoteka, prenos (537,29 KB)
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Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo OI - Onkološki inštitut Ljubljana
Povzetek:Aiming at improving treatment individualization in patients with prostate cancer treated with combination of external beam radiotherapy and high-dose-rate brachytherapy to boost the dose to prostate (HDRB-B), the objective was to evaluate factors that have potential impact on obstructive urination problems (OUP) after HDRB-B. Patients and methods. In the follow-up study 88 patients consecutively treated with HDRB-B at the Institute of Oncology Ljubljana in the period 2006-2011 were included. The observed outcome was deterioration of OUP (DOUP) during the follow-up period longer than 1 year. Univariate and multivariate relationship analysis between DOUP and potential risk factors (treatment factors, patients% characteristics) was carried out by using binary logistic regression. ROC curve was constructed on predicted values and the area under the curve (AUC) calculated to assess the performance of the multivariate model. Results. Analysis was carried out on 71 patients who completed 3 years of follow-up. DOUP was noted in 13/71 (18.3%) of them. The results of multivariate analysis showed statistically significant relationship between DOUP and anticoagulation treatment (OR 4.86, 95% C.I. limits: 1.21-19.61, p = 0.026). Also minimal dose received by 90% of the urethra volume was close to statistical significance (OR = 1.23; 95% C.I. limits: 0.98-1.07, p = 0.099). The value of AUC was 0.755. Conclusions. The study emphasized the relationship between DOUP and anticoagulation treatment, and suggested the multivariate model with fair predictive performance. This model potentially enables a reduction of DOUP after HDRB-B. It supports the belief that further research should be focused on urethral sphincter as a critical structure for OUP.
Ključne besede:prostate cancer, high-dose-rate brachytherapy boost, urinary stricture, obstructive urination problems
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.03.2016
Založnik:Association of Radiology and Oncology
Leto izida:2016
Št. strani:str. 94-103, VII
Številčenje:Vol. 50, no. 1
Izvor:Ljubljana
PID:20.500.12556/DiRROS-18858 Novo okno
UDK:616.65-006-08
ISSN pri članku:1318-2099
DOI:10.1515/raon-2015-0010 Novo okno
COBISS.SI-ID:2275707 Novo okno
Avtorske pravice:by Authors
Datum objave v DiRROS:30.04.2024
Število ogledov:525
Število prenosov:255
Metapodatki:XML DC-XML DC-RDF
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Gradivo je del revije

Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:prostata, rak (medicina), brahiradioterapija, obsevanje, obstruktivne težave, urinarni sistem


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