| Title: | The influence of folate pathway polymorphisms on high-dose methotrexaterelated toxicity and survival in children with non-Hodgkin malignant lymphoma |
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| Authors: | ID Erčulj, Nina (Author)
ID Faganel Kotnik, Barbara (Author)
ID Debeljak, Maruša (Author)
ID Jazbec, Janez (Author)
ID Dolžan, Vita (Author) |
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| Files: |  URL - Source URL, visit http://www.degruyter.com/view/j/raon.2014.48.issue-3/raon-2013-0076/raon-2013-0076.xml?format=INT
 PDF - Presentation file, download (487,58 KB)
MD5: D75DAF0268C6BC92D803AE7F4A11BD9D
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  OI - Institute of Oncology
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| Abstract: | Background. We evaluated the influence of folate pathway polymorphisms on high-dose methotrexate (HD-MTX) related toxicity in paediatric patients with T-cell non-Hodgkin lymphoma (NHL). Patients and methods. In total, 30 NHL patients were genotyped for selected folate pathway polymorphisms. Results. Carriers of at least one MTHFR 677T allele had significantly higher MTX area under the time-concentration curve levels at third MTX cycle (P = 0.003). These patients were also at higher odds of leucopoenia (P = 0.006) or thrombocytopenia (P = 0.041) and had higher number of different HD-MTX-related toxicity (P = 0.035) compared to patients with wild-type genotype. Conclusions. Our results suggest an important role of MTHFR 677C>T polymorphism in the development of HD-MTXrelated toxicity in children with NHL. |
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| Keywords: | childhood, non-Hodgkin lymphoma, polymorphism |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.09.2014 |
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| Publisher: | Association of Radiology and Oncology |
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| Year of publishing: | 2014 |
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| Number of pages: | str. 289-292, V |
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| Numbering: | Vol. 48, no. 3 |
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| Source: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-18696  |
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| UDC: | 616-006 |
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| ISSN on article: | 1318-2099 |
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| COBISS.SI-ID: | 31525337 |
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| Copyright: | by Authors |
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| Note: | Soavtorji: Barbara Faganel Kotnik, Marusa Debeljak, Janez Jazbec, Vita Dolzan;
Vzporedni stvar. nasl. in izvleček v slov. na str. V;
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| Publication date in DiRROS: | 16.04.2024 |
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| Views: | 453 |
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| Downloads: | 288 |
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