| Naslov: | The influence of folate pathway polymorphisms on high-dose methotrexaterelated toxicity and survival in children with non-Hodgkin malignant lymphoma |
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| Avtorji: | ID Erčulj, Nina (Avtor)
ID Faganel Kotnik, Barbara (Avtor)
ID Debeljak, Maruša (Avtor)
ID Jazbec, Janez (Avtor)
ID Dolžan, Vita (Avtor) |
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| Datoteke: |  URL - Izvorni URL, za dostop obiščite http://www.degruyter.com/view/j/raon.2014.48.issue-3/raon-2013-0076/raon-2013-0076.xml?format=INT
 PDF - Predstavitvena datoteka, prenos (487,58 KB)
MD5: D75DAF0268C6BC92D803AE7F4A11BD9D
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  OI - Onkološki inštitut Ljubljana
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| Povzetek: | Background. We evaluated the influence of folate pathway polymorphisms on high-dose methotrexate (HD-MTX) related toxicity in paediatric patients with T-cell non-Hodgkin lymphoma (NHL). Patients and methods. In total, 30 NHL patients were genotyped for selected folate pathway polymorphisms. Results. Carriers of at least one MTHFR 677T allele had significantly higher MTX area under the time-concentration curve levels at third MTX cycle (P = 0.003). These patients were also at higher odds of leucopoenia (P = 0.006) or thrombocytopenia (P = 0.041) and had higher number of different HD-MTX-related toxicity (P = 0.035) compared to patients with wild-type genotype. Conclusions. Our results suggest an important role of MTHFR 677C>T polymorphism in the development of HD-MTXrelated toxicity in children with NHL. |
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| Ključne besede: | childhood, non-Hodgkin lymphoma, polymorphism |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 01.09.2014 |
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| Založnik: | Association of Radiology and Oncology |
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| Leto izida: | 2014 |
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| Št. strani: | str. 289-292, V |
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| Številčenje: | Vol. 48, no. 3 |
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| Izvor: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-18696  |
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| UDK: | 616-006 |
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| ISSN pri članku: | 1318-2099 |
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| COBISS.SI-ID: | 31525337 |
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| Avtorske pravice: | by Authors |
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| Opomba: | Soavtorji: Barbara Faganel Kotnik, Marusa Debeljak, Janez Jazbec, Vita Dolzan;
Vzporedni stvar. nasl. in izvleček v slov. na str. V;
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| Datum objave v DiRROS: | 16.04.2024 |
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| Število ogledov: | 447 |
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| Število prenosov: | 287 |
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| Metapodatki: |    |
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