| Title: | Capecitabine in adjuvant radiochemotherapy for gastric adenocarcinoma |
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| Authors: | ID Oblak, Irena (Author)
ID Skoblar Vidmar, Marija (Author)
ID Anderluh, Franc (Author)
ID Velenik, Vaneja (Author)
ID Jeromen, Ana (Author)
ID But-Hadžić, Jasna (Author) |
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| Files: |  PDF - Presentation file, download (519,56 KB)
MD5: 81C786D883587160E5E0E01C94A2EB37
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  OI - Institute of Oncology
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| Abstract: | Background. In patients with non-metastatic gastric cancer surgery still remains the treatment of choice. Postoperative radiochemotherapy with 5-fluorouracil and leucovorin significantly improves the treatment outcome. The oral fluoropyrimidines, such as capecitabine, mimic continuous 5-fluorouracil infusion, are at least as effective as 5-fluorouracil, and such treatment is more comfortable for the patients. Patients and methods. In the period from October 2006 to December 2009, 101 patients with gastric cancer in stages Ib-IIIc were treated with postoperative chemoradiation with capecitabine. Distal subtotal resection of the stomach was performed in 46.3%, total resection in 50.5% and multivisceral resection in 3.2% of patients. The main endpoints of this study were loco-regional control (LRC), disease-free survival (DFS), disease-specific survival (DSS) and overall survival (OS). The rates of acute side-effects were also estimated. Results. Seventy-seven percent of patients completed the treatment according to the protocol. The median followup time of all patients was 3.9 years (range: 0.4-6.3 years) and in survivors it was 4.7 years (range: 3.2-6.3 years). No death occurred due to the therapy. Acute toxicity, such as nausea and vomiting, stomatitis, diarrhoea, hand-foot syndrome and infections of grade 3 or 4, occurred in 5%, 1%, 2%, 8.9% and 18.8% of patients, respectively. On the close-out date 63.4% patients were still alive and with no signs of the disease. The 4-years follow-up survey showed that LRC, DFS, DSS and OS were 95.5%, 69.2%, 70.7%, and 66.2%, respectively. Higher pN-stage and splenectomy were found to be independent prognostic factors for all four types of survival and perineural invasion and lower treatment intensity for DFS, DSS and OS. |
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| Keywords: | gastric cancer, adjuvant therapy, radiochemotherapy |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.06.2014 |
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| Publisher: | Association of Radiology and Oncology |
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| Year of publishing: | 2014 |
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| Number of pages: | str. 189-196 |
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| Numbering: | Vol. 48, no. 2 |
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| Source: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-18658  |
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| UDC: | 616.3 |
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| ISSN on article: | 1318-2099 |
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| DOI: | 10.2478/raon-2013-0065 |
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| COBISS.SI-ID: | 1617531 |
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| Copyright: | by Authors |
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| Publication date in DiRROS: | 11.04.2024 |
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| Views: | 455 |
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| Downloads: | 174 |
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