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Title: The role of extracellular vesicles in phenotypic cancer transformation Authors: ID Ogorevc, Eva (Author) ID Kralj-Iglič, Veronika (Author) ID Veranič, Peter (Author) Files: URL - Source URL, visit https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794874/   PDF - Presentation file, download (864,38 KB) MD5: BFB6198050508AD1681F277D84B988D8   Language: English Typology: 1.02 - Review Article Organization: OI - Institute of Oncology Abstract: Background. Cancer has traditionally been considered as a disease resulting from gene mutations. New findings in biology are challenging gene-centered explanations of cancer progression and redirecting them to the non-genetic origins of tumorigenicity. It has become clear that intercellular communication plays a crucial role in cancer progression. Among the most intriguing ways of intercellular communication is that via extracellular vesicles (EVs). EVs are membrane structures released from various types of cells. After separation from the mother membrane, EVs become mobile and may travel from the extracellular space to blood and other body fluids. Conclusions. Recently it has been shown that tumour cells are particularly prone to vesiculation and that tumour-derived EVs can carry proteins, lipids and nucleic acids causative of cancer progression. The uptake of tumour-derived EVs by noncancerous cells can change their normal phenotype to cancerous. The suppression of vesiculation could slow down tumour growth and the spread of metastases. The purpose of this review is to highlight examples of EV-mediated cancer phenotypic transformation in the light of possible therapeutic applications. Publication status: Published Publication version: Version of Record Publication date: 01.09.2013 Publisher: Association of Radiology and Oncology Year of publishing: 2013 Number of pages: str. 197-205 Numbering: Vol. 47, no. 3 Source: Ljubljana PID: 20.500.12556/DiRROS-18593  UDC: 576:616-006 ISSN on article: 1318-2099 DOI: 10.2478/raon-2013-0037  COBISS.SI-ID: 269123584  Copyright: by Authors Note: Naslov v kazalu in el. verziji se razlikuje od naslova članka na str. 197; Izvleček in vzporedni stvarni naslov v slov. na str. I-VII; Besedilo članka v angl.; Publication date in DiRROS: 03.04.2024 Views: 72 Downloads: 29 Metadata:     Cite this work Plain text BibTeX EndNote XML EndNote/Refer RIS ABNT ACM Ref AMA APA Chicago 17th Author-Date Harvard IEEE ISO 690 MLA Vancouver : Copy citation

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Record is a part of a journal

Title:	Radiology and oncology
Shortened title:	Radiol. oncol.
Publisher:	Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:	1318-2099
COBISS.SI-ID:	32649472

Secondary language

Language:	Slovenian
Title:	[Pomen zunajceličnih veziklov v rakasti transformaciji celic]
Keywords:	rak (medicina), tumorske celice, mikrovezikli, biologija celice

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