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Naslov:
The role of extracellular vesicles in phenotypic cancer transformation
Avtorji:
ID
Ogorevc, Eva
(Avtor)
ID
Kralj-Iglič, Veronika
(Avtor)
ID
Veranič, Peter
(Avtor)
Datoteke:
URL - Izvorni URL, za dostop obiščite
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794874/
PDF - Predstavitvena datoteka,
prenos
(864,38 KB)
MD5: BFB6198050508AD1681F277D84B988D8
Jezik:
Angleški jezik
Tipologija:
1.02 - Pregledni znanstveni članek
Organizacija:
OI - Onkološki inštitut Ljubljana
Povzetek:
Background. Cancer has traditionally been considered as a disease resulting from gene mutations. New findings in biology are challenging gene-centered explanations of cancer progression and redirecting them to the non-genetic origins of tumorigenicity. It has become clear that intercellular communication plays a crucial role in cancer progression. Among the most intriguing ways of intercellular communication is that via extracellular vesicles (EVs). EVs are membrane structures released from various types of cells. After separation from the mother membrane, EVs become mobile and may travel from the extracellular space to blood and other body fluids. Conclusions. Recently it has been shown that tumour cells are particularly prone to vesiculation and that tumour-derived EVs can carry proteins, lipids and nucleic acids causative of cancer progression. The uptake of tumour-derived EVs by noncancerous cells can change their normal phenotype to cancerous. The suppression of vesiculation could slow down tumour growth and the spread of metastases. The purpose of this review is to highlight examples of EV-mediated cancer phenotypic transformation in the light of possible therapeutic applications.
Status publikacije:
Objavljeno
Verzija publikacije:
Objavljena publikacija
Datum objave:
01.09.2013
Založnik:
Association of Radiology and Oncology
Leto izida:
2013
Št. strani:
str. 197-205
Številčenje:
Vol. 47, no. 3
Izvor:
Ljubljana
PID:
20.500.12556/DiRROS-18593
UDK:
576:616-006
ISSN pri članku:
1318-2099
DOI:
10.2478/raon-2013-0037
COBISS.SI-ID:
269123584
Avtorske pravice:
by Authors
Opomba:
Naslov v kazalu in el. verziji se razlikuje od naslova članka na str. 197; Izvleček in vzporedni stvarni naslov v slov. na str. I-VII; Besedilo članka v angl.;
Datum objave v DiRROS:
03.04.2024
Število ogledov:
284
Število prenosov:
259
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Gradivo je del revije
Naslov:
Radiology and oncology
Skrajšan naslov:
Radiol. oncol.
Založnik:
Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:
1318-2099
COBISS.SI-ID:
32649472
Sekundarni jezik
Jezik:
Slovenski jezik
Naslov:
[Pomen zunajceličnih veziklov v rakasti transformaciji celic]
Ključne besede:
rak (medicina)
,
tumorske celice
,
mikrovezikli
,
biologija celice
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