| Title: | Cathepsin X in serum from patients with colorectal cancer: relation to prognosis |
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| Authors: | ID Vižin, Tjaša (Author)
ID Christensen, Ib Jarle (Author)
ID Nielsen, Hans Jørgen (Author)
ID Kos, Janko (Author) |
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| Files: |  URL - Source URL, visit http://versita.metapress.com/content/65w42w03260l5508/fulltext.pdf
 PDF - Presentation file, download (360,31 KB)
MD5: 596EB0E05235BB461E8391228CBB3620
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  OI - Institute of Oncology
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| Abstract: | Background. Up-regulation of lysosomal cysteine protease cathepsin X (Cat X) is associated with disorders of the immune system and neurodegenerative diseases, while its role in the development and progression of cancer is less understood. Enhanced secretion of pro-Cat X was observed in malignant processes, and therefore, the level of total serum Cat X rather than the active enzyme may better reflect the tumour status. Patients and methods. Seventy-seven patients with colorectal cancer (CRC) were included in a retrospective study. Blood samples were collected prior to therapy. Using ELISA, the values of total Cat X were measured in serum. Groups of healthy persons (n=77), patients with adenomas (n=77) and patients with non-neoplastic findings (n=77) were included. Results. Significant differences between the group of colorectal patients and the groups of healthy persons, adenoma patients and patients with non-malignant findings could not be shown (p=0.89). Within the group of CRC, higher levels of total Cat X significantly correlated to shorter overall survival (HR=2.08, 95% CI:1.07-4.05, p=0.028). Conclusions. Total serum Cat X could be a useful prognostic indicator for determining survival of patients with CRC. Increased serum levels of total CatX may reflect more aggressive tumour cell phenotypes and suggest the involvement of Cat X in processes involved in later stages of tumour progression. |
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| Keywords: | cysteine cathepsins, cathepsin X, colorectal cancer, prognosis, serum biomarker |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.01.2012 |
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| Publisher: | Association of Radiology and Oncology |
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| Year of publishing: | 2012 |
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| Number of pages: | str. 207-212, II |
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| Numbering: | Vol. 46, no. 3 |
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| Source: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-18517  |
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| UDC: | 577.1+616.35 |
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| ISSN on article: | 1318-2099 |
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| DOI: | 10.2478/v10019-012-0040-0 |
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| COBISS.SI-ID: | 3297393 |
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| Copyright: | by Authors |
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| Publication date in DiRROS: | 21.03.2024 |
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| Views: | 1054 |
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| Downloads: | 649 |
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