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Title:Cathepsin X in serum from patients with colorectal cancer: relation to prognosis
Authors:ID Vižin, Tjaša (Author)
ID Christensen, Ib Jarle (Author)
ID Nielsen, Hans Jørgen (Author)
ID Kos, Janko (Author)
Files:URL URL - Source URL, visit http://versita.metapress.com/content/65w42w03260l5508/fulltext.pdf
 
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MD5: 596EB0E05235BB461E8391228CBB3620
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Background. Up-regulation of lysosomal cysteine protease cathepsin X (Cat X) is associated with disorders of the immune system and neurodegenerative diseases, while its role in the development and progression of cancer is less understood. Enhanced secretion of pro-Cat X was observed in malignant processes, and therefore, the level of total serum Cat X rather than the active enzyme may better reflect the tumour status. Patients and methods. Seventy-seven patients with colorectal cancer (CRC) were included in a retrospective study. Blood samples were collected prior to therapy. Using ELISA, the values of total Cat X were measured in serum. Groups of healthy persons (n=77), patients with adenomas (n=77) and patients with non-neoplastic findings (n=77) were included. Results. Significant differences between the group of colorectal patients and the groups of healthy persons, adenoma patients and patients with non-malignant findings could not be shown (p=0.89). Within the group of CRC, higher levels of total Cat X significantly correlated to shorter overall survival (HR=2.08, 95% CI:1.07-4.05, p=0.028). Conclusions. Total serum Cat X could be a useful prognostic indicator for determining survival of patients with CRC. Increased serum levels of total CatX may reflect more aggressive tumour cell phenotypes and suggest the involvement of Cat X in processes involved in later stages of tumour progression.
Keywords:cysteine cathepsins, cathepsin X, colorectal cancer, prognosis, serum biomarker
Publication status:Published
Publication version:Version of Record
Publication date:01.01.2012
Publisher:Association of Radiology and Oncology
Year of publishing:2012
Number of pages:str. 207-212, II
Numbering:Vol. 46, no. 3
Source:Ljubljana
PID:20.500.12556/DiRROS-18517 New window
UDC:577.1+616.35
ISSN on article:1318-2099
DOI:10.2478/v10019-012-0040-0 New window
COBISS.SI-ID:3297393 New window
Copyright:by Authors
Publication date in DiRROS:21.03.2024
Views:496
Downloads:222
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Title:Katepsin X v serumu bolnikov z rakom črevesja: povezanost z napovedjo poteka bolezni


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