20.500.12556/DiRROS-18517 Cathepsin X in serum from patients with colorectal cancer: relation to prognosis Katepsin X v serumu bolnikov z rakom črevesja: povezanost z napovedjo poteka bolezni Background. Up-regulation of lysosomal cysteine protease cathepsin X (Cat X) is associated with disorders of the immune system and neurodegenerative diseases, while its role in the development and progression of cancer is less understood. Enhanced secretion of pro-Cat X was observed in malignant processes, and therefore, the level of total serum Cat X rather than the active enzyme may better reflect the tumour status. Patients and methods. Seventy-seven patients with colorectal cancer (CRC) were included in a retrospective study. Blood samples were collected prior to therapy. Using ELISA, the values of total Cat X were measured in serum. Groups of healthy persons (n=77), patients with adenomas (n=77) and patients with non-neoplastic findings (n=77) were included. Results. Significant differences between the group of colorectal patients and the groups of healthy persons, adenoma patients and patients with non-malignant findings could not be shown (p=0.89). Within the group of CRC, higher levels of total Cat X significantly correlated to shorter overall survival (HR=2.08, 95% CI:1.07-4.05, p=0.028). Conclusions. Total serum Cat X could be a useful prognostic indicator for determining survival of patients with CRC. Increased serum levels of total CatX may reflect more aggressive tumour cell phenotypes and suggest the involvement of Cat X in processes involved in later stages of tumour progression. cysteine cathepsins cathepsin X colorectal cancer prognosis serum biomarker true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-03-21 12:42:06 2024-03-21 12:42:07 2024-03-22 03:48:33 0000-00-00 00:00:00 2012 0 0 str. 207-212, II no. 3 Vol. 46 2012 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2012-01-01 577.1+616.35 1318-2099 10.2478/v10019-012-0040-0 3297393 http://versita.metapress.com/content/65w42w03260l5508/fulltext.pdf 1 0f44e9a5-e778-11ee-9dd4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25235 RAZ_Vizin_Tjasa_2012.pdf RAZ_Vizin_Tjasa_2012.pdf 1 596EB0E05235BB461E8391228CBB3620 c4b41526105975f2cb53af795664b886c5b239b97135304f28a05e4a70f6509b 3ae7295f-e778-11ee-9dd4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25236 Onkološki inštitut Ljubljana 0 0 0