| Title: | Prognostic relevance of urokinase plasminogen activator and its inhibitors in patients with breast cancer |
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| Authors: | ID Borštnar, Simona (Author)
ID Čufer, Tanja (Author)
ID Vrhovec, Ivan (Author)
ID Rudolf, Zvonimir (Author) |
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| Files: |  PDF - Presentation file, download (548,70 KB)
MD5: 5D6A8E94AC57146124C672D2C3CEEDEB
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  OI - Institute of Oncology
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| Abstract: | Urokinase plasminogen activator (uPA) and its inhibitors, PAI-1 and PAI-2, play an important role in iritercellular tissue degradation, thus promoting tumor cell invasion into the adjoining structures and metastasizing. Our studywas aimed to assess a possible prognostic value of uPA, PAI-1 and PAI-2 in a retrospective series of 87 patients with breast cancer stage I-III, whosecytosols were stored in the archives of the, Institute of Oncology in Ljubljana. The median follow-up was 35 months. The prognostic value of the established prognostic factors and uPA, PAI-1 and PAI-2 were evaluated by means of univariate statistical analysis and partial multivariate models. The obtained uPA values were very low and did not correlate with the disease free survival, whereas PAI-1 and PAI-2 significantly influenced the time to the first recurrence. Patients with PAI-1 values above 5 ng/mg proteins had statistically significantly worse disease free survival than the patients withlower PAI-1 values (58% vs. 85%). In the case of PAI-2, the situation wasjust the opposite: the patients with PAI-2 values exceeding 6.4 ng/mg proteins had statistically significantly better 3-year disease free survival than the patients with lower values (90% vs. 60%). Both, PAI-1 and PAl-2 retained their independent prognostic value, irrespective of the addition of the established prognostic factors to partial multivariate models, and only with locally advanced disease the prognostic value of PAI-1 was greater than that of PAI-2. |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.03.1999 |
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| Publisher: | Slovenian Medical Association - Slovenian Association of Radiology, Nuclear Medicine Society, Slovenian Society far Radiotherapy and Oncology, and Slovenian Cancer Society |
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| Year of publishing: | 1999 |
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| Number of pages: | str. 43-53 |
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| Numbering: | Letn. 33, št. 1 |
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| Source: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-17910  |
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| UDC: | 616-006 |
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| ISSN on article: | 1318-2099 |
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| COBISS.SI-ID: | 9752281 |
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| Copyright: | by Authors |
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| Note: | BSDOCID43310;
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| Publication date in DiRROS: | 22.01.2024 |
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| Views: | 330 |
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| Downloads: | 81 |
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