20.500.12556/DiRROS-17910 Prognostic relevance of urokinase plasminogen activator and its inhibitors in patients with breast cancer Napovedni pomen urokinaznega aktivatorja plazminogena in njegovih inhibitorjev pri bolnicah z rakom dojk Urokinase plasminogen activator (uPA) and its inhibitors, PAI-1 and PAI-2, play an important role in iritercellular tissue degradation, thus promoting tumor cell invasion into the adjoining structures and metastasizing. Our studywas aimed to assess a possible prognostic value of uPA, PAI-1 and PAI-2 in a retrospective series of 87 patients with breast cancer stage I-III, whosecytosols were stored in the archives of the, Institute of Oncology in Ljubljana. The median follow-up was 35 months. The prognostic value of the established prognostic factors and uPA, PAI-1 and PAI-2 were evaluated by means of univariate statistical analysis and partial multivariate models. The obtained uPA values were very low and did not correlate with the disease free survival, whereas PAI-1 and PAI-2 significantly influenced the time to the first recurrence. Patients with PAI-1 values above 5 ng/mg proteins had statistically significantly worse disease free survival than the patients withlower PAI-1 values (58% vs. 85%). In the case of PAI-2, the situation wasjust the opposite: the patients with PAI-2 values exceeding 6.4 ng/mg proteins had statistically significantly better 3-year disease free survival than the patients with lower values (90% vs. 60%). Both, PAI-1 and PAl-2 retained their independent prognostic value, irrespective of the addition of the established prognostic factors to partial multivariate models, and only with locally advanced disease the prognostic value of PAI-1 was greater than that of PAI-2. Urokinazni aktivator plazminogena (u-PA), in njegova inhibitorja (PAI- 1 in PAI-2) igrajo pomembno vlogo pri razgradnji medceličnega tkiva in s tem pri prodoru tumorskih celic v okolico ter metastaziranju. Namen naše raziskave je bil ugotoviti morebitno napovedno vrednost uPA, PAI-1 in PAI-2 v retrospektivni seriji 87 bolnic z rakom dojke stadijev I-III, njihove citosolehranimo na Onkološkem inštitutu v Ljubljani. Srednja opazovalna doba je bila 35 mesecev. Napovedni pomen uveljavljenih napovednih dejavnikov ter uPA, PAI-1 in PAI-2 smo ocenjevali z univariatno statistično analizo in delnimi multivariatnimi modeli. Vrednost uPA so bile zelo nizke in niso korelirale s preživetjem brez znamenj bolezni, PAI-1 in PAI-2 pa sta značilno vplivala na čas prve ponovitve bolezni. Bolnice, ki so imele vrednost PAI-1 večjo od 5ng/mg pro- teinov, so imele statistično značilno slabše preživetje brez znamenj bolezni kot bolnice z manjšimi vrednostmi (58% vs 85% , p = 0.0046). PAI-2 je pokazal nasprotno sliko, bolnice z vred- nostmi PAI-2 večjimi od 6.4 ng/mg proteinov so imele statistično značilno boljše triletno preživetje brez znamenj bolezni kot bolnice z manjšimi vrednostmi ( 90% vs 48%, Ir= 0.0178). PAI-1 in PAI-2 sta ohranila svojo neodvisno napovedno vrednost ob dodajanju uveljavljenih napovednih dejavnikov v delne multivariatne modele in le lokalna razširjenost bolezni je pokazala večjo napovedno moč od PAI-1 in PAI-2. true false true Slovenian Medical Association - Slovenian Association of Radiology, Nuclear Medicine Society, Slovenian Society far Radiotherapy and Oncology, and Slovenian Cancer Society Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-01-22 10:45:47 2024-01-22 10:45:48 2024-01-23 03:41:23 0000-00-00 00:00:00 1999 0 0 BSDOCID43310; str. 43-53 št. 1 Letn. 33 March 1999 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 1999-03-01 616-006 1318-2099 9752281 RAZ_Borstnar_Simona_1999.pdf RAZ_Borstnar_Simona_1999.pdf 1 5D6A8E94AC57146124C672D2C3CEEDEB c50e89dc61cbc4f0b47457e41f7b2d54d0aab576f0924e2ae67035973c71123f 3680f992-b90b-11ee-b0d4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=24286 Onkološki inštitut Ljubljana 0 0 0