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Title: Molecular alterations induced in drug-resistant cells Authors: ID Osmak, Maja (Author) Files: PDF - Presentation file, download (2,17 MB) MD5: 5E8EB6F3BDA79EC90229E36A359F71E4   Language: English Typology: 1.01 - Original Scientific Article Organization: OI - Institute of Oncology Abstract: The major obstacle to the ultimate success in cancer therapy is the ability oftumor cells to develop resistance to anticancer drugs. Several molecular mechanisms have been suggested to be involved in drugresistance: a) decrease in the intracellular drug accumulation (increased activity of membrane transporters such as P-glycoprotein or multidrug-resistance-associated protein), b) changes in intracellular detoxification system (increased concentrations of glutathione or metallothioneins, or increased activity of related enzymed), c) alteration in nuclear enzymes (enhanced DNA repair and/orbetter tolerance of DNA damage, decreased acitivty of topoisomerases), d) altered expression of oncogenes (inducing increased level of protective molecules in cells or the inhibition of apoptosis). Drug resistance is a multifactorial phenomenon. The complexity of molecular alterations in drug-resistant cells is and will stay the main problem for the successful treatment of cancer. Publication status: Published Publication version: Version of Record Publication date: 01.01.1998 Publisher: Slovenian Medical Society - Section of Radiology ; Croatian Medical Association - Croatian Society of Radiology Year of publishing: 1998 Number of pages: str. 19-33 Numbering: Letn. 32, št. 1 Source: Ljubljana PID: 20.500.12556/DiRROS-17904  UDC: 61 ISSN on article: 1318-2099 COBISS.SI-ID: 7823065  Copyright: by Authors Note: Life sciences '97 and 2nd Slovenian-Croatian meeting on Molecular oncology today; 1997 Oct 16-19; Gozd Martuljek; BSDOCID37102; Publication date in DiRROS: 19.01.2024 Views: 678 Downloads: 135 Metadata:    Cite this work Plain text BibTeX EndNote XML EndNote/Refer RIS ABNT ACM Ref AMA APA Chicago 17th Author-Date Harvard IEEE ISO 690 MLA Vancouver : Copy citation

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Record is a part of a journal

Title:	Radiology and oncology
Shortened title:	Radiol. oncol.
Publisher:	Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:	1318-2099
COBISS.SI-ID:	32649472

Secondary language

Language:	Slovenian
Title:	Molecularne spremembe v celicah rezistentnih na citostatike

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