20.500.12556/DiRROS-17904 Molecular alterations induced in drug-resistant cells Molecularne spremembe v celicah rezistentnih na citostatike The major obstacle to the ultimate success in cancer therapy is the ability oftumor cells to develop resistance to anticancer drugs. Several molecular mechanisms have been suggested to be involved in drugresistance: a) decrease in the intracellular drug accumulation (increased activity of membrane transporters such as P-glycoprotein or multidrug-resistance-associated protein), b) changes in intracellular detoxification system (increased concentrations of glutathione or metallothioneins, or increased activity of related enzymed), c) alteration in nuclear enzymes (enhanced DNA repair and/orbetter tolerance of DNA damage, decreased acitivty of topoisomerases), d) altered expression of oncogenes (inducing increased level of protective molecules in cells or the inhibition of apoptosis). Drug resistance is a multifactorial phenomenon. The complexity of molecular alterations in drug-resistant cells is and will stay the main problem for the successful treatment of cancer. true false true Slovenian Medical Society - Section of Radiology ; Croatian Medical Association - Croatian Society of Radiology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-01-19 13:41:46 2024-01-19 13:41:46 2024-01-20 03:46:22 0000-00-00 00:00:00 1998 0 0 Life sciences '97 and 2nd Slovenian-Croatian meeting on Molecular oncology today; 1997 Oct 16-19; Gozd Martuljek; BSDOCID37102; str. 19-33 št. 1 Letn. 32 1998 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 1998-01-01 61 1318-2099 7823065 RAZ_Osmak_Maja_1998.pdf RAZ_Osmak_Maja_1998.pdf 1 5E8EB6F3BDA79EC90229E36A359F71E4 8a1a41e634192a380570133ff53c8de70126d4b59699cd42e34add2dbafe0c86 503e77c4-b6c8-11ee-b0d4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=24276 Onkološki inštitut Ljubljana 0 0 0