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Title:Impact of 10-day bed rest on serum levels of irisin and markers of musculoskeletal metabolism
Authors:ID Oranger, Angela (Author)
ID Storlino, Giuseppina (Author)
ID Dicarlo, Manuela (Author)
ID Zerlotin, Roberta (Author)
ID Pignataro, Patrizia (Author)
ID Sanesi, Lorenzo (Author)
ID Narici, Marco Vicenzo (Author)
ID Pišot, Rado (Author)
ID Šimunič, Boštjan (Author)
ID Colaianni, Graziana (Author)
Files:URL URL - Source URL, visit https://doi.org/10.1096/fj.202201005RR
 
.pdf PDF - Presentation file, download (827,16 KB)
MD5: 68F26ED76294F64114ECA1596E81C10F
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo ZRS Koper - Science and Research Centre Koper
Abstract:The bed rest (BR) is a ground-based model to simulate microgravity mimicking skeletal-muscle alterations as in spaceflight. Molecular coupling between bone and muscle might be involved in physiological and pathological conditions. Thus, the new myokine irisin and bone-muscle turnover markers have been studied during and after 10 days of BR. Ten young male individuals were subjected to 10 days of horizontal BR. Serum concentrations of irisin, myostatin, sclerostin, and haptoglobin were assessed, and muscle tissue gene expression on vastus lateralis biopsies was determined. During 10-days BR, we observed no significant fluctuation levels of irisin, myostatin, and sclerostin. Two days after BR (R+2), irisin serum levels significantly decreased while myostatin, sclerostin, and haptoglobin were significantly increased compared with BR0. Gene expression of myokines, inflammatory molecules, transcription factors, and markers of muscle atrophy and senescence on muscle biopsies were not altered, suggesting that muscle metabolism of young, healthy subjects is able to adapt to the hypomobility condition during 10-day BR. However, when subjects were divided according to irisin serum levels at BR9, muscle ring finger-1 mRNA expression was significantly lower in subjects with higher irisin serum levels, suggesting that this myokine may prevent the triggering of muscle atrophy. Moreover, the negative correlation between p21 mRNA and irisin at BR9 indicated a possible inhibitory effect of the myokine on the senescence marker. In conclusion, irisin could be a prognostic marker of hypomobility-induced muscle atrophy, and its serum levels could protect against muscle deterioration by preventing and/or delaying the expression of atrophy and senescence cellular markers.
Publication status:Published
Publication version:Version of Record
Article acceptance date:11.11.2022
Publication date:07.12.2022
Year of publishing:2023
Number of pages:str. 1-13
Numbering:Vol. 37, iss. 1
PID:20.500.12556/DiRROS-15911 New window
UDC:612.74:796.01
ISSN on article:1530-6860
DOI:10.1096/fj.202201005RR New window
COBISS.SI-ID:133716995 New window
Copyright:© 2022 The Authors.
Note:Nasl. z nasl. zaslona; Soavtorji: Giuseppina Storlino, Manuela Dicarlo, Roberta Zerlotin, Patrizia Pignataro, Lorenzo Sanesi, Marco Narici, Rado Pišot, Bostjan Simunič, Graziana Colaianni, Maria Grano, Silvia Colucci; Opis vira z dne 13. 12. 2022; Članek št. e22668;
Publication date in DiRROS:13.12.2022
Views:567
Downloads:323
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Record is a part of a journal

Title:The FASEB journal
Shortened title:FASEB j.
Publisher:The Federation
ISSN:1530-6860
COBISS.SI-ID:19804967 New window

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:07.12.2022

Secondary language

Language:Slovenian
Keywords:gibalna neaktivnost, bed rest, celična senesenca, haptoglobin, irisin, mišična atrofija, miostatin, sklerostin, physical inactivity, cell senescence, muscle atrophy, myostatin, sclerostin


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