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Title:Dynamic contrast-enhanced MRI in malignant pleural mesothelioma : prediction of outcome based on DCE-MRI measurements in patients undergoing cytotoxic chemotherapy
Authors:ID Vivoda Tomšič, Martina, Klinika Golnik, Medicinska fakulteta UL (Author)
ID Korošec, Peter, Klinika Golnik, Fakulteta za farmacijo UL (Author)
ID Kovač, Viljem, Onkološki inštitut (Author)
ID Bisdas, Sotirios (Author)
ID Šurlan Popović, Katarina, Onkološki inštitut (Author)
Files:.pdf PDF - Presentation file, download (1,55 MB)
MD5: 88521B170EAE3D84233A652990669508
URL URL - Source URL, visit
Typology:1.01 - Original Scientific Article
Organization:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:The malignant pleural mesothelioma (MPM) response rate to chemotherapy is low. The identification of imaging biomarkers that could help guide the most effective therapy approach for individual patients is highly desirable. Our aim was to investigate the dynamic contrast-enhanced (DCE) MR parameters as predictors for progression-free (PFS) and overall survival (OS) in patients with MPM treated with cisplatin-based chemotherapy. Methods: Thirty-two consecutive patients with MPM were enrolled in this prospective study. Pretreatment and intratreatment DCE-MRI were scheduled in each patient. The DCE parameters were analyzed using the extended Tofts (ET) and the adiabatic approximation tissue homogeneity (AATH) model. Comparison analysis, logistic regression and ROC analysis were used to identify the predictors for the patient's outcome. Results: Patients with higher pretreatment ET and AATH-calculated Ktrans and ve values had longer OS (P≤.006). Patients with a more prominent reduction in ET-calculated Ktrans and kep values during the early phase of chemotherapy had longer PFS (P =.008). No parameter was identified to predict PFS. Pre-treatment ET-calculated Ktrans was found to be an independent predictive marker for longer OS (P=.02) demonstrating the most favourable discrimination performance compared to other DCE parameters with an estimated sensitivity of 89% and specificity of 78% (AUC 0.9, 95% CI 0.74-0.98, cut off > 0.08 min-1). Conclusions: In the present study, higher pre-treatment ET-calculated Ktrans values were associated with longer OS. The results suggest that DCE-MRI might provide additional information for identifying MPM patients that may respond to chemotherapy.
Keywords:cisplatin, magnetic resonance imaging, mesothelioma
Publication status in journal:Published
Article version:Publisher's version of article
Place of publishing:Velika Britanija
Publisher:Springer Nature
Year of publishing:2022
Number of pages:str. 191-1-191-11
Numbering:Vol. 22, iss. 1
PID:20.500.12556/DiRROS-14960 New window
ISSN on article:1471-2407
DOI:10.1186/s12885-022-09277-x New window
COBISS.SI-ID:99703043 New window
Copyright:© The Author(s) 2022
Note:Nasl. z nasl. zaslona; Opis vira z dne 2. 2. 2022;
Publication date in DiRROS:06.04.2022
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Record is a part of a journal

Title:BMC cancer
Shortened title:BMC Cancer
Publisher:BioMed Central
COBISS.SI-ID:2434324 New window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:20.02.2022

Secondary language

Keywords:cisplatin, slikanje z magnetno resonanco, mezoteliom