20.500.12556/DiRROS-14960 Dynamic contrast-enhanced MRI in malignant pleural mesothelioma : prediction of outcome based on DCE-MRI measurements in patients undergoing cytotoxic chemotherapy The malignant pleural mesothelioma (MPM) response rate to chemotherapy is low. The identification of imaging biomarkers that could help guide the most effective therapy approach for individual patients is highly desirable. Our aim was to investigate the dynamic contrast-enhanced (DCE) MR parameters as predictors for progression-free (PFS) and overall survival (OS) in patients with MPM treated with cisplatin-based chemotherapy. Methods: Thirty-two consecutive patients with MPM were enrolled in this prospective study. Pretreatment and intratreatment DCE-MRI were scheduled in each patient. The DCE parameters were analyzed using the extended Tofts (ET) and the adiabatic approximation tissue homogeneity (AATH) model. Comparison analysis, logistic regression and ROC analysis were used to identify the predictors for the patient's outcome. Results: Patients with higher pretreatment ET and AATH-calculated Ktrans and ve values had longer OS (P≤.006). Patients with a more prominent reduction in ET-calculated Ktrans and kep values during the early phase of chemotherapy had longer PFS (P =.008). No parameter was identified to predict PFS. Pre-treatment ET-calculated Ktrans was found to be an independent predictive marker for longer OS (P=.02) demonstrating the most favourable discrimination performance compared to other DCE parameters with an estimated sensitivity of 89% and specificity of 78% (AUC 0.9, 95% CI 0.74-0.98, cut off > 0.08 min-1). Conclusions: In the present study, higher pre-treatment ET-calculated Ktrans values were associated with longer OS. The results suggest that DCE-MRI might provide additional information for identifying MPM patients that may respond to chemotherapy. cisplatin magnetic resonance imaging mesothelioma cisplatin slikanje z magnetno resonanco mezoteliom true false true Springer Nature Angleški jezik Ni določen © The Author(s) 2022 Neznano 2022-04-06 11:57:35 2022-04-06 11:57:36 2022-08-21 03:34:20 0000-00-00 00:00:00 2022 0 Velika Britanija 0 Nasl. z nasl. zaslona; Opis vira z dne 2. 2. 2022; str. 191-1-191-11 iss. 1 Vol. 22 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-07 1471-2407 10.1186/s12885-022-09277-x 99703043 12885_2022_Article_9277.pdf 12885_2022_Article_9277.pdf 1 88521B170EAE3D84233A652990669508 30152a9ee32d24951e5fb09617b640cb5b1b69e5382db7f972fc78bfa28e9cdd e1e43cc7-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=19422 https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8859879/pdf/12885_2022_Article_9277.pdf 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=19423 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0